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Analysis of single plant cells provides insights into natural product biosynthesis

ATHENS An international team of researchers from the University of Georgia and the Max Planck Institute for Chemical Ecology in Germany have discovered a promising strategy to decode the ....

Chenxin Li , University Of Georgia , College Of Agricultural , Max Planck Institute For Chemical Ecology , Environmental Sciences , Max Planck Institute , Chemical Ecology , Nature Chemical , Applied Genetic Technologies ,

Comprehensive analysis of single plant cells

In a new study published in Nature Chemical Biology, an international team of researchers from the University of Georgia, USA, and the Max Planck Institute for Chemical Ecology in Jena, Germany, presents a promising strategy for elucidating metabolic pathways for plant compounds of medicinal importance. The research team studied the biosynthesis of two alkaloids from the plant Catharanthus roseus that are used in human medicine as anti-cancer agents. The genes for the formation of these active substances are expressed in different cell types. By using single-cell analyses, the scientists were able to discover new genes important for biosynthesis and show that the intermediates of the metabolic pathway accumulate in specific cell types. The researchers predict that this methodological approach will provide important new insights into the biosynthesis of many other natural products from the plant kingdom. (Nature Chemical Biology, May 15, 2023, doi: 10.1038/s41589-023-01327-0). ....

United States , University Of Georgia , Lorenzo Caputi , Sarah Oconnor , Chenxin Li , Robin Buell , Method Of Research , Department Of Natural Product Biosynthesis , Department Of Natural Product Biosynthesis In Jena , Alkaloid Biosynthesis Project Group , University Of Georgia Center , Professor At Georgia University , Applied Genetic Technologies , Natural Product Biosynthesis , Saraho Connor , Natural Product ,