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Themis is indispensable for IL-2 and IL-15 signaling in T cells

Themis is indispensable for IL-2 and IL-15 signaling in T cells
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Celltrace Violet , Lck Cre , Gene Ontology , Kyoto Encyclopedia , Agilent Seahorse ,

SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models


Science for just $15 USD.
Short circuiting solid tumors
Two major hurdles in chimeric antigen receptor (CAR) T cell therapy for solid tumors are ensuring specificity to tumor cells without affecting healthy cells and avoiding tumor escape due to antigen loss. To address these challenges, Hyrenius-Wittsten
et al. and Choe
et al. developed synthetic Notch (synNotch)–CAR T cells targeting solid tumor antigens and used them to treat mouse models of mesothelioma, ovarian cancer, and glioblastoma. In both studies, the authors demonstrated that synNotch-CAR T cells were better at controlling tumors than traditional CAR T cells and did not result in toxicity or damage to healthy tissue. These results suggest that synNotch-CAR T cells may be an effective treatment strategy for solid tumors. ....

United Kingdom , Takara Bio , Facsaria Iiiu , Chan Zuckerberg Biohub , Celltrace Violet , B Ebert Addgene , Essen Bioscience , P Steinberger Addgene , Swedish Society For Medical Research , National Cancer Institute , Transfection Reagent Mirus Bio , Kleberg Foundation , Worthington Biochemical Corporation , Software Essen Bioscience , Swedish Research Council , Cancer Research United Kingdom , Graphpad Software , Parker Institute For Cancer Immunotherapy , Ge Healthcare , Helen Diller Family Comprehensive Cancer Center , Hitrap His , Vector Laboratories , Jackson Immunoresearch Laboratories , Thermo Fisher Scientific , Lenti Transfection Reagent , Mirus Bio ,

CAR T: Dual-targeted cell therapy prevent relapsed myeloma


Expert Insight: CAR T: Dual-targeted cell therapy to prevent relapsed multiple myeloma: Your questions answered
Watch this on-demand webinar to find out how targeting B-cell maturation antigen and GPRC5D simultaneously could help to prevent tumor cell escape
15 Dec 2020
Carlos Fernández de Larrea, University of Barcelona and Rogier M. Reijmers, LUMICKS
There have been significant advances in the treatment of relapsed multiple myeloma over the past decade, which in turn has resulted in an increase in survival rates. A very promising and novel approach is the application of chimeric antigen receptor (CAR) T cells, which have already demonstrated unprecedented clinical successes in the treatment of pediatric lymphoblastic leukemia. ....

Comunidad Autonoma De Cataluna , Noord Holland , Celltrace Violet , Carlos Fern , Rogierm Reijmers , University Of Barcelona , Expert Insight , Associate Professor , Principal Scientist , காமுனிடட தன்னாட்சி டி கடலுள் , நூற்த் ஹாலண்ட் , கார்லோஸ் ஃபெர்ன் , பல்கலைக்கழகம் ஆஃப் பார்சிலோனா , நிபுணர் நுண்ணறிவு , இணை ப்ரொஃபெஸர் , ப்ரிந்ஸிபல் விஞ்ஞானி ,