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Science for just $15 USD. Short circuiting solid tumors Two major hurdles in chimeric antigen receptor (CAR) T cell therapy for solid tumors are ensuring specificity to tumor cells without affecting healthy cells and avoiding tumor escape due to antigen loss. To address these challenges, Hyrenius-Wittsten et al. and Choe et al. developed synthetic Notch (synNotch)–CAR T cells targeting solid tumor antigens and used them to treat mouse models of mesothelioma, ovarian cancer, and glioblastoma. In both studies, the authors demonstrated that synNotch-CAR T cells were better at controlling tumors than traditional CAR T cells and did not result in toxicity or damage to healthy tissue. These results suggest that synNotch-CAR T cells may be an effective treatment strategy for solid tumors. ....
Rating: Application Area:Live cell imaging and analysis The Incucyte SX5 is an easy-to-use live-cell imaging technology, saving our scientists time in both experimental set-up and monitoring whilst providing exceptional, previously unobtainable readouts. Protocols for a wide range of lab-based assays are freely available and easy to follow. Many of our scientists have already switched many of their traditional lab-based assays to use the Incucyte technology instead. The ability to monitor your cells in real-time remotely is a hugely attractive feature to our scientists especially during this pandemic. The technology provides user-friendly built-in software to easily evaluate your experimental data offering a range of options to present your data graphically, via FACS plots or in movies – all of which are easily transferable to other software for presentation or publication purposes. Both the sales reps and application specialists were extremely helpful during ....
Rating: Application Area:Live cell imaging and analysis The Incucyte SX5 is an easy-to-use live-cell imaging technology, saving our scientists time in both experimental set-up and monitoring whilst providing exceptional, previously unobtainable readouts. Protocols for a wide range of lab-based assays are freely available and easy to follow. Many of our scientists have already switched many of their traditional lab-based assays to use the Incucyte technology instead. The ability to monitor your cells in real-time remotely is a hugely attractive feature to our scientists especially during this pandemic. The technology provides user-friendly built-in software to easily evaluate your experimental data offering a range of options to present your data graphically, via FACS plots or in movies – all of which are easily transferable to other software for presentation or publication purposes. Both the sales reps and application specialists were extremely helpful during ....