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Use of ADCs in the Second-Line Treatment of HER2+ mBC

Experts introduce the antibody-drug conjugates (ADCs) trastuzumab emtansine (T-DM1) and trastuzumab deruxtecan (T-DXd) and discuss clinical trial findings and potential use in special patient populations, such as those with brain metastases. ....

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HER2CLIMB-02: Tucatinib and T-DM1 in HER2+ Breast Cancer

Megan Kruse, MD, discusses the HER2CLIMB-02 study and the impact it may have on the HER2+ metastatic breast cancer treatment landscape. ....

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Trastuzumab deruxtecan superior to physician's choice treatment in patients with metastatic HER2-positive breast cancer

1. Progression-free survival was greater in the trastuzumab group compared to standard care (17.8 months vs. 6.9 months). 2. Drug-related interstitial lung disease was more common with patients receiving trastuzumab deruxtecan. Evidence Rating Level: 1 (Excellent) Study Rundown: A large proportion of breast cancers are characterized by overexpression of HER2 receptors. While first-line therapy for ....

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Patient Profile: A 68-Year-Old Woman With HER2+ Metastatic Breast Cancer

Expert oncologist Virginia Kaklamani, MD, DSc, shares her perspectives on a patient case of HER2+ metastatic breast cancer (mBC) treated with multiple lines of therapy. ....

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Preliminary Ongoing Results with CYT-0851 in Combination with Capecitabine or Gemcitabine in Advanced Solid Tumors Show Early Clinical Activity and Generally Well Tolerated Safety Profile

- CYT-0851 has demonstrated early activity in combination with capecitabine or gemcitabine in advanced solid tumors and a generally well tolerated safety profile in a heavily pretreated population of. | June 3, 2023 ....

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