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Cancer cells hijack the 3D structure of DNA


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In cancer, a lot of biology goes awry: Genes mutate, molecular processes change dramatically, and cells proliferate uncontrollably to form entirely new tissues that we call tumors. Multiple things go wrong at different levels, and this complexity is partly what makes cancer so difficult to research and treat.
So it stands to reason that cancer researchers focus their attention where all cancers begin: the genome. If we can understand what happens at the level of DNA, then we can perhaps one day not just treat but even prevent cancers altogether.
This drive has led a team of researchers from EPFL and the University of Lausanne (UNIL) to make a breakthrough discovery concerning a critical genetic aberration that occurs in cancer. Working together, the groups of Elisa Oricchio (EPFL) and Giovanni Ciriello (UNIL) have used a novel algorithm-based method to study how cancer cells re-organize the 3D structure of their DNA in order to ramp up the activity of cancer- ....

United States , Giovanni Ciriello , Elisa Oricchio , Alexander Calder , Nature Communications , Swiss Cancer Center Leman , Swiss Institute Of Bioinformatics , Aix Marseille University , University Of Lausanne , Nature Genetics , Cancer Center Leman , Marseille University , ஒன்றுபட்டது மாநிலங்களில் , ஜியோவானி சிரியெல்லோ , அலெக்சாண்டர் கால்டர் , இயற்கை தகவல்தொடர்புகள் , சுவிஸ் புற்றுநோய் மையம் லெமன் , சுவிஸ் நிறுவனம் ஆஃப் உயிர் தகவலியல் , ஐஸ் மார்சேய் பல்கலைக்கழகம் , இயற்கை ஜெநெடிக்ஸ் , மார்சேய் பல்கலைக்கழகம் ,