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New method combines synthetic biology with AI in the cell-free quest for new antibiotics

New method combines synthetic biology with AI in the cell-free quest for new antibiotics
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Tobias Erb , Samir Pandi , Max Planck Institute For Terrestrial Microbiology , Max Planck Institute , Nature Communications , Lung Institute , Bundeswehr Institute For Microbiology , University Of Marburg , Max Planck Institute For Biophysics , Terrestrial Microbiology , Bundeswehr Institute ,

Frontiers | Isolation of Brucella inopinata from a White's tree frog (Litoria caerulea): pose exotic frogs a potential risk to human health?

Cold-blooded hosts, particularly exotic frogs, have become a newly recognized reservoir for atypical Brucella species and strains worldwide, but their pathogenicity to humans remains largely unknown. Here we report the isolation of a B. inopinata strain (FO700662) from a diseased White's Tree Frog (Litoria caerulea) in Switzerland. Originally identified as Ochrobactrum based on its rapid growth and biochemical profile, strain FO700622 was positive for the Brucella-specific markers bcsp31 and IS711. It showed the specific banding pattern of B. inopinata in conventional Bruce-ladder multiplex PCR and also had identical 16S rRNA and recA gene sequences as B. inopinata. Subsequent genome sequencing followed by core genome-based MLST (cgMLST) analysis using 2704 targets (74% of the total chromosome) revealed only 173 allelic differences compared to the type strain of B. inopinata BO1T, while previously considered the closest related strain BO2 differed in 2046 alleles. The overall avera ....

New York , United States , Nordrhein Westfalen , Bad Kissingen , Baden Wüberg , Nord Pas De Calais , Maisons Alfort , Îe De France , Papua New Guinea , Gabriele Echle , Laboklin Gmb , Endo Agar Becton Dickinson , Ridom Gmb , Al Dahouk , Figtree Rambaut , Bruker Daltonik Gmb , Jbrowse Skinner , National Institute Of Allergy , Robert Koch Institute , Institut National , Department Of Health , Ministry Of Health , Viral Bioinformatics Resource Center Wattam , National Institutes Of Health , Library Preparation , Human Services ,

Spain identifies possible new monkeypox cluster in Canaries

Monkeypox word is seen on the screen of a smartphone and the World Health Organization (WHO) logo in the background. Authorities in Australia, France and Germany confirmed their first cases of monkeypox on Friday as the normally rare disease continues to crop up in a growing number of countries arou. ....

United States , United Kingdom , Central African Republic , Central African , The Netherlands , El Pa , Gran Canaria , Bavarian Health Ministry , Germany Robert Koch Institute , World Health Organization , Bundeswehr Institute Of Microbiology , Health Ministry , Maspalomas Gay Pride , Ichilov Hospital , Tel Aviv , West African , Bundeswehr Institute , North Rhine Westphalia , Robert Koch Institute , West Africa , Democratic Republic ,