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ADC Doublets Represent a Promising Novel Approach for Treatment-Resistant mUC

Bradley A. McGregor, MD, expands on the feasibility and safety considerations addressed through the design and methodology of the DAD study; highlights dose-limiting toxicities and early responses seen with sacituzumab govitecan plus enfortumab vedotin in treatment-resistant mUC; and explains how these results support further investigation of other ADC doublets. ....

Dana Farber Cancer Institute , United States , Bradleya Mcgregor , Genitourinary Oncology At Dana Farber Cancer Institute , Harvard Medical School , Lank Center , Antibody Drug Conjugate , Genitourinary Oncology , Urothelial Cancer , Esmo Congress , Sacituzumab Govitecan , Enfortumab Vedotin ,

Sacituzumab Govitecan Plus Enfortumab Vedotin Shows Early Promise in Metastatic Urothelial Carcinoma

Combining sacituzumab govitecan-hziy and enfortumab vedotin-ejfv was safe, feasible, and produced high and early response rates in patients with treatment-resistant metastatic urothelial cancer. ....

Bradleya Mcgregor , Dana Farber Cancer Institute , Antibody Drug Conjugate , Bayesian Optimal Internal Design , Urothelial Cancer , Esmo Congress , Sacituzumab Govitecan , Enfortumab Vedotin ,

Cabozantinib Plus Nivolumab and Ipilimumab Elicits Meaningful Activity in RCCvh

Triplet therapy with cabozantinib, nivolumab, and ipilimumab demonstrated clinical meaningful activity in patients with renal cell carcinoma with variant histologies. ....

Kaplan Meier , Bradleya Mcgregor , Clinical Research , Dana Farber Cancer Institute , Lank Center , Asco Annual Meeting ,

Three-Drug Regimen Is Promising Across Kidney Cancer Subtypes

Cabometyx, Opdivo and Yervoy led to high disease control rates across different subgroups of patients with kidney cancer, research showed. ....

Opdivo Yervoy , Bradleya Mcgregor , Clinical Research , Dana Farber Cancer Institute , Lank Center , Kidney Cancer , Asco Annual Meeting ,