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Usual interstitial pneumonia as a stand-alone diagnostic entity: the case for a paradigm shift?

Usual interstitial pneumonia (UIP) is characterised by a distinctive morphological
and radiological appearance that was considered the pathognomonic hallmark of idiopathic
pulmonary fibrosis (IPF). However, this peculiar lung remodelling pattern is also
seen in other fibrotic interstitial lung diseases, including hypersensitivity pneumonitis,
and connective tissue diseases. In this Personal View, we advocate the designation
of a UIP pattern as a single, discrete diagnostic entity, amalgamating its primary
form and secondary processes in disorders such as hypersensitivity pneumonitis (hypersensitivity
pneumonitis with UIP), rheumatoid arthritis (rheumatoid arthritis with UIP), and others. ....

United States , Mashonaland East , United Kingdom , King Jr , Clin Rheumatol , Roy Chowdhury , American Thoracic Society European Respiratory , European Respiratory Society American Thoracic , European Respiratory Society , American Thoracic Society , American Thoracic , Arthritis Rheum , Bone Spine , European Respiratory , Rev Respir Med , Englj Med , Envisia Genomic Classifier , Respir Med , Death Discov ,

Systemic sclerosis

Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue
disease. Once considered an untreatable and unpredictable condition, research advancements
have improved our understanding of its disease pathogenesis and clinical phenotypes
and expanded our treatment armamentarium. Early and accurate diagnosis is essential,
while ongoing efforts to risk stratify patients have a central role in predicting
both organ involvement and disease progression. A holistic approach is required when
choosing the optimal therapeutic strategy, balancing the side-effect profile with
efficacy and tailoring the treatment according to the goals of care of the patient. ....

Ma An , United States , United Kingdom , Sri Lanka , France General , J Clin Rheumatol , Respir Pulm , Semin Hematol , Almeida Chaves , Chemother Pharmacol , Coll Cardiol , Matucci Cerinic , Los Angeles , Clin Rheumatol , J Clin Gastroenterol , Acta Gastroenterol Latinoam , Medsger Jr , Scandj Gastroenterol , Scleroderma Intervention Network , Canadian Scleroderma Research Group , Scleroderma Clinical Trials Consortium Gastrointestinal Tract , International Scleroderma Renal Crisis Study , Eurj Health Econ , International Scleroderma Renal Crisis , Research Group , European Reference Network ,

DRESS syndrome

DRESS syndrome
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Elsevier Ltd , Mahmoud Abdelnabi , Clinical Picture , Bone Spine ,