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Acute Malaria Characterised by Thrombocytopenia

Determining platelet counts in Malawian children and in adults during acute P. falciparum malaria and a month post treatment. Click to read.. ....

Eteläuomen Läi , United States , Unigold Trinity Brotch , Laboratory Technologist , Department Of Paediatrics , Kamuzu University Of Health Sciences Kuhe , University Of Malawi , Windows Graphpad Software , Beit Cure International Hospital , College Of Medicine Research , Clinical Research Programme , Ethics Committee , College Of Medicine , Abbott Laboratories , College Of Medicine Co , Sub Saharan Africa , Blantyre Malaria Project , Queen Elizabeth Central Hospital , Blantyre Coma Score , Healthy Controls , Parasitemia Levels , Platelet Counts , Study Participants , Presented Values , Ranges Provided , Case Report Forms ,

Incidence of chikungunya virus infections among Kenyan children with neurological disease, 2014–2018: A cohort study

In a cohort study, Doris K. Nyamwaya, Mark Otiende, and colleagues investigate the incidence of chikungunya virus infection-associated neurological illness among children younger than 16 years of age in Kilifi County, Kenya, between 2014-2018. ....

United Kingdom , Nairobi Area , Indian Ocean , Harvard Dataverse , Global Health Research , National Institute For Health Research , Research Programme , Kilifi Health , Mahidol Oxford Tropical Medicine Research Unit , Data Governance Committee , Kilifi County , Creative Commons Attribution License , Wellcome Trust Research , National Institute , Health Research , Wellcome Trust , Open Access , Blantyre Coma Score , Kilifi County Hospital , Demographic Surveillance System , East African ,

Incidence of chikungunya virus infections among Kenyan children with neurological disease, 2014–2018: A cohort study

In a cohort study, Doris K. Nyamwaya, Mark Otiende, and colleagues investigate the incidence of chikungunya virus infection-associated neurological illness among children younger than 16 years of age in Kilifi County, Kenya, between 2014-2018. ....

United Kingdom , Nairobi Area , Indian Ocean , Harvard Dataverse , Global Health Research , National Institute For Health Research , Research Programme , Kilifi Health , Mahidol Oxford Tropical Medicine Research Unit , Data Governance Committee , Kilifi County , Creative Commons Attribution License , Wellcome Trust Research , National Institute , Health Research , Wellcome Trust , Open Access , Blantyre Coma Score , Kilifi County Hospital , Demographic Surveillance System , East African , Chikungunya Virus , Cerebrospinal Fluid , Chikungunya Infection , Reverse Transcriptase Polymerase Chain Reaction ,

Non-traumatic coma in young children in Benin: are viral and bacterial infections gaining ground on cerebral malaria? | Infectious Diseases of Poverty

While malaria morbidity and mortality have declined since 2000, viral central nervous system infections appear to be an important, underestimated cause of coma in malaria-endemic Eastern Africa. We aimed to describe the etiology of non-traumatic comas in young children in Benin, as well as their management and early outcomes, and to identify factors associated with death. From March to November 2018, we enrolled all HIV-negative children aged between 2 and 6 years, with a Blantyre Coma Score ≤ 2, in this prospective observational study. Children were screened for malaria severity signs and assessed using a systematic diagnostic protocol, including blood cultures, malaria diagnostics, and cerebrospinal fluid analysis using multiplex PCR. To determine factors associated with death, univariate and multivariate analyses were performed. From 3244 admissions, 84 children were included: malaria was diagnosed in 78, eight of whom had a viral or bacterial co-infection ....

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Expression of CD11a, CD11b, CD11c and CD18

Reduced expression on neutrophils of adhesion molecules and activation markers during acute stages of the infection regardless of the clinical type of malaria. ....

Eteläuomen Läi , San Diego , United States , Becton Dickinson , Department Of Paediatrics , University Of Malawi , College Of Medicine Research , Beit Cure International Hospital , Malawi Liverpool Wellcome Trust Clinical Research Programme , Ethics Committee , Graphpad Software , College Of Medicine , Blantyre Malaria , Queen Elizabeth Central Hospital , Blantyre Coma , Blantyre Coma Score , Medicine Research , Cellquest Pro , Graphpad Prism , Neutrophils During Acute , Neutrophils During Recovery ,