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Biotech partnership to develop new therapies

Biotech partnership to develop new therapies
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La Trobe , Lesley Cheng Neurodegeneration , David Haylock , Susan Dodds , Ed Husic , Australian National University , University Of Queensland , Trobe University , Vivazome Therapeutics Pty Ltd , Trobe University Technology Enterprise Centre , Trobe Research , Seerpharma Pty Ltd , Research Centres Projects , Biomarker Group , Trobe University City Of The , Australian Government , Cooperative Research Centres Projects , Seerpharma Pty , Trobe Deputy Vice Chancellor , Industry Engagement , Professor Susan Dodds , Neurodegeneration Biology , Science Ed Husic , Innovation Precinct , University City , Zome Therapeutics Pty Ltd ,

High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Excessive inflammation is a characteristic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, particularly in patients that are hospitalized with coronavirus disease 2019 (COVID-19). Here, Hoepel et al. investigated how human antibodies specific to SARS-CoV-2 spike protein may contribute to exacerbated inflammation. The authors found that spike protein–specific antibodies from patients with COVID-19 who were hospitalized had altered glycosylation, with an enrichment in low-fucosylated antibodies. These antibodies were able to activate human macrophages in vitro to secrete proinflammatory cytokines. Thus, altered antibody glycosylation may contribute to disease severity in COVID-19.

Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show ....

Noord Holland , United States , Miltenyi Biotec , U Cytech Biosciences , Melinda Gates Foundation , Dutch Federation Of University Medical Centers , Innovative Medicines Initiative , Amsterdam Cardiovascular Sciences , Agilent Technologies , Dutch Heart Foundation , Netherlands Organization For Health Research , European Union , Graphpad Software , Discovery Workbench Software , European Union Horizon , Proinflammatory Panel , European Commission , Vrije Universiteit Medical Center , Transatlantic Network Grant , Ethical Committee , Netherlands Cardiovascular Research Initiative , Netherlands Heart Foundation , Sanquin Blood Supply Foundation , Royal Netherlands Academy Of Sciences , Chemokine Panel , Biomarker Group ,