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Targeting the Notch pathway with gamma secretase inhibitor improves outcomes in patients with rare cancers

Significant improvement in progression-free survival and response rate combined with reduced symptoms and better quality of life are reported as outcomes of a new treatment approach for patients with desmoid tumors, which are benign, but locally aggressive and invasive soft tissue tumors. ....

Baden Wüberg , Bernd Kasper , Emily Henderson , Cancer Center , Mannheim Cancer Center , Jean Yves Blay , Yves Blay , Desmoid Tumor , Otch Signalling ,