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Novel treatment for polycythemia vera shows promise in clinical trial

A novel treatment for polycythemia vera, a potentially fatal blood cancer, demonstrated the ability to control overproduction of red blood cells, the hallmark of this malignancy and many of its debilitating symptoms in a multi-center clinical trial led by the Icahn School of Medicine at Mount Sinai. ....

United States , Ronald Hoffman , Yelena Ginzburg , Mount Sinai Health System , Protagonist Therapeutics Inc , Icahn School Of Medicine At Mount Sinai , Sinai Health , Icahn School , New England Journal , Associate Professor , Medical Oncology , Icahn Mount Sinai , Medical Director , Mount Sinai Hospital , Mount Sinai , Protagonist Therapeutics , Blood Cancer , Bell Production , Clinical Trial , Iron Deficiency , Polycythemia Vera , Red Blood Cells ,

Small-molecule A485 mobilizes white blood cells on demand

New study reveals a small molecule that can selectively mobilize white blood cells, offering potential treatments for diseases with abnormal leukocyte counts. ....

Liji Thomas , Bone Marrow , Bell Production , Central Nervous System , Nervous System ,

Gene activity plays key role in immune cell production, study shows

As people age or become ill, their immune systems can become exhausted and less capable of fighting off viruses such as the flu or COVID-19. ....

United States , Melissa Valenzuela , Yeachan Lee , Jorge Contreras , Anna Nogalska , Rong Lu , Adnany Chowdhury , Mary Vergel Rodriguez , National Cancer Institute , California Institute For Regenerative Medicine , Keck School Of Medicine , National Institutes Of Health , Leukemia Lymphoma Society Scholar , Leukemia Lymphoma Society , Flu Lab , Lu Lab Our , National Institutes , Science Advances , Lymphoma Society , Keck School , California Institute , Regenerative Medicine , Bell Production , Bone Marrow , Cell Biology , Covid 19 ,

New insights into the cellular programs that promote resolution of inflammation during aging

Aging is associated with chronic, nonresolving inflammation, or "inflammaging," that can lead to tissue dysfunction. ....

United States , Katherinec Macnamara , Gabrielle Fredman , Department Of Immunology , Department Of Molecular , Albany Medical College , American Journal , Cellular Physiology , Microbial Disease , Bone Marrow , Bell Production , Nex Vivo , Egg Protein ,

Maternal exercise shapes early yolk sac growth, varies with baby's sex

This study in Scientific Reports reveals that maternal physical activity impacts yolk sac development in early pregnancy, with effects varying based on gestational age and the sex of the embryo, underscoring the nuanced relationship between maternal behavior and embryonic growth. ....

Scientific Reports , Physical Activity , Bell Production , Gastrointestinal Tract , Protein Synthesis ,