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A pan-approach against blood cancer preserving hematopoiesis

A group of scientists from Basel University Hospital have designed an antibody-drug conjugate (ADC) that eliminated blood cancer cells without attacking healthy hematopoietic stem cells (HSCs), which they modified by base editing and transplanted to renew an altered blood system. They achieved this by focusing on the panhematopoietic marker CD45. ....

Basel University Hospital ,

Cimeio Therapeutics Announces Publication in Nature Demonstrating That CD45 ADC and Shielded HSCs Represent a Potentially Universal Therapy for Blood Cancers

Selective and complete eradication of leukemic cells with an ADC targeting the pan-blood marker CD45 Engineered hematopoietic Stem Cells (HSCs) shielded from the CD45-targeting ADC maintain ....

Steve Edelson , Lukas Jeker , Stefanie Urlinger , University Of Basel , Cimeio Therapeutics Inc , Basel University Hospital , Stem Cells , Chief Scientific Officer , Cimeio Therapeutics , Ihr Portfolio ,

IV Thrombolysis Offers No Benefit for Mild Stroke

Minor ischemic stroke patients with intracranial occlusion should not be treated with IV thrombolysis, a new trial has concluded. ....

United Kingdom , France General , New Zealand , Urs Fischer , Shelagh Coutts , Simona Sacco , National Institutes Of Health Stroke Scale , Basel University Hospital , University Of Calgary , European Stroke Organization Conference , National Institutes , Health Stroke Scale , Rankin Scale , Guillaume Turc , Paris Cit ,

Microdosing LSD: Are there benefits? What about risks?

It doesn't take much LSD, short for lysergic acid diethylamide, to substantially alter a person's state of consciousness. Compared with many other substances, the amounts are very small, says Dr Volker Auwärter, director of the forensic toxicology laboratory at the University of Freiburg Medical Centre in Germany: "Upwards of 50, 100 micrograms are said to be a psychedelic dose." The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) calls the hallucinogen "one of the most potent d ....

New Zealand , Matthias Liechti , University Of Freiburg Medical Centre , Department Of Biomedicine , Basel University Hospital , University Of Auckland School Pharmacy , European Monitoring Centre For Drugs , Basel University Psychiatric Clinics , Division Of Clinical Pharmacology , University Of Auckland , Freiburg Medical Centre , European Monitoring Centre , Drug Addiction , Clinical Pharmacology , Biological Psychiatry , Lsd Microdosing , Side Effects , Felix Müller , Randomized Controlled Trial , Psychedelic Substances , R Matthias Liechti , Psychedelic Experience ,

Newly Discovered Virus Kills 'Sleeping' Bacteria - The Good Men Project

Newly Discovered Virus Kills 'Sleeping' Bacteria - The Good Men Project
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