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Non-Covalent BTK Inhibitor Yields High Response Rate in Pretreated CLL

73% of patients with prior exposure to covalent BTK inhibitors responded ....

Noord Holland , United States , Mike Bassett , Jennifer Woyach , Barbara Eichhorst , Arnonp Kater , Ohio University Comprehensive Cancer Center , University Of Cologne , University Of Amsterdam , New England Journal , England Journal , Englj Med ,

Venetoclax Plus Obinutuzumab With or Without Ibrutinib Improves Undetectable MRD Rates in Fit Patients With CLL

The combination of venetoclax and obinutuzumab with or without ibrutinib generated higher rates of undetectable minimal residual disease (MRD) and progression-free survival vs chemoimmunotherapy in fit patients with chronic lymphocytic leukemia. ....

Barbara Eichhorst , Study Group , International Workshop , University Of Cologne , New England Journal , Chronic Lymphocytic Leukemia , Gaia Cll13 Trial ,

CLL: Venetoclax Combos Top First-Line Chemoimmunotherapy

A combination of venetoclax, ibrutinib, and obinutuzumab outperforms first-line chemoimmunotherapy for chronic lymphocytic leukemia in otherwise fit adults with few comorbidities. ....

Barbara Eichhorst , John Byrd , Jennifer Woyach , University Of Cologne Germany , Ohio State University , University Of Cincinnati , New England Journal , Chronic Lymphocytic Leukemia , Biologic Therapy , Antineoplastic Drug , Nti Cancer Agents , Monoclonal Antibody , Tyrosine Kinase Inhibitor , Residual Disease , Tyrosine Kinase , Atrial Fibrillation , F Atrial Fibrillation ,

Time-limited venetoclax-based regimens prolong PFS vs. chemoimmunotherapy in CLL

Time-limited venetoclax, obinutuzumab and ibrutinib or venetoclax plus obinutuzumab prolonged PFS compared with chemoimmunotherapy among fit, previously untreated patients with chronic lymphocytic leukemia, according to study results.The preplanned interim analysis of the international, randomized phase 3 GAIA/CLL13 trial, presented during European Hematology Association Hybrid 2022 Congress, ....

Barbara Eichhorst , Jennifer Southall , Roche Ltd , European Hematology Association , University Hospital Cologne , European Hematology Association Hybrid , Merck Sharp ,

Venetoclax Combos Improve Progression-Free Survival in CLL

Venetoclax/obinutuzumab as well as a triple combo with ibrutinib demonstrated better PFS in fit patients with CLL vs chemo, but higher rates of serious adverse events with ibrutinib remain a concern. ....

Barbara Eichhorst , University Of Cologne , European Hematology Association , Elect Ant , Medscape Medical , Chronic Lymphocytic Leukemia , Antineoplastic Drug , Nti Cancer Agents , Alignant Neoplasia , Biologic Therapy , Precision Medicine , Targeted Therapy ,