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Total Neoadjuvant Therapy Improves Rectal Cancer Pathologic Response


Dec 18, 2020
Treatment approach has potential disease-free survival advantage
Patients with locally advanced rectal cancer treated with total neoadjuvant therapy followed by surgery had a higher chance of achieving a pathologic complete response than those treated with standard therapy involving concurrent chemotherapy followed by surgery and adjuvant chemotherapy, a meta-analysis of 7 trials involving more than 2,400 patients revealed.
The pooled prevalence of pathologic complete response (PCR) was 29.9% in the total neoadjuvant therapy (TNT) patients and 14.9% in the standard treatment group.
Surgical outcomes, including rates of sphincter-preserving surgery and ileostomy, did not differ significantly between the two treatment groups, and just 3 studies included data on disease-free survival while none included data on overall survival. ....

United States , Psalynn Boyles , Noam Vanderwalde , Axel Grothey , Research Institute , Kansas University Medical Center , Tennessee West Cancer Center , Anup Kasi , West Cancer Center , Contributing Writer , ஒன்றுபட்டது மாநிலங்களில் , ஆராய்ச்சி நிறுவனம் , கன்சாஸ் பல்கலைக்கழகம் மருத்துவ மையம் , டென்னசி மேற்கு புற்றுநோய் மையம் , அனுப்பி காசி , மேற்கு புற்றுநோய் மையம் ,