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Study provides deeper understanding of how membrane remodeling works in human cells

In a study published in the prestigious scientific journal PNAS, Umeå researchers describe a natural product-like molecule, Tantalosin, that inhibits interaction between two proteins in complexes that reshape membranes inside the cell. ....

Anastasia Knyazeva , Kasturika Shankar , Herbert Waldmann , Lars Anders Carlson , Yaowen Wu , Scilifelab In Karolinska Institute , Max Planck Institute Dortmund , Department Of Chemistry , Department Of Chemistry At Ume , Professor Herbert Waldmann , Karolinska Institute , Small Molecules ,

SCA4 genetic breakthrough: Unveiling the cause of a devastating neurological disease

Some families call it a trial of faith. Others just call it a curse. The progressive neurological disease known as spinocerebellar ataxia 4 (SCA4) is a rare condition, but its effects on patients and their families can be severe. ....

United States , Salt Lake Valley , University Of Utah , Stefan Pulst , K Pattie Figueroa , Spencer Fox Eccles School Of Medicine , University Of Utah Health , Spencer Fox Eccles School , Neurological Disease , Spinocerebellar Ataxia ,

Genetic variants linked to Parkinson's risk from pesticide exposure

A new UCLA Health study found certain genetic variants could help explain how long-term pesticide exposure could increase the risk of Parkinson's disease. ....

Los Angeles , United States , Central Valley , Jeff Bronstein , Brent Fogel , Kimberly Paul , Beate Ritz , University Of California , Los Angeles Health Sciences , Angeles Health , Human Genetics , Arkinson 39s Disease ,

Preserving autophagy protects from muscle aging

A protein whose expression decreases during aging could be key to preserving cellular maintenance mechanisms and preventing the progressive loss of muscle mass that occurs during aging. Scientists from the Institute for Research in Biomedicine (IRB) and the University of Barcelona (UB) have revealed the role of the TP53INP2 protein in autophagy and the effects of its reduction on skeletal muscle during aging. ....

Comunidad Autonoma De Cataluna , University Of Barcelona , Institute For Research , Bioworld Science , Muscle Atrophy , Institute For Research In Biomedicine , Muscle Aging , Altos Labs ,

Mitochondrial depletion in axons linked to protein accumulation in neurodegenerative diseases

Researchers from Tokyo Metropolitan University have identified how proteins collect abnormally in neurons, a feature of neurodegenerative diseases like Alzheimer's. ....

Japan General , Kanae Ando , Novartis Foundation Japan , Sasakawa Scientific Research Grant , Scientific Research On Challenging Exploratory , National Institute Of Genetics , Takeda Science Foundation , Strategic Research Fund For Social Engagement , Tokyo Metropolitan University , Japan Foundation For , Hoansha Foundation Grant , Amyotrophic Lateral Sclerosis , Associate Professor Kanae Ando , Japan Foundation , Novartis Foundation , Scientific Research , Challenging Research , National Institute , Research Fund , Neurodegenerative Diseases ,