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New clinical study aims to prevent type 1 diabetes in children


Credit: Andreas Pfohl, NOZY Films GmbH
Around one in 300 children and adolescents are diagnosed with the autoimmune disease type 1 diabetes by 18 years of age. Around 90 percent of patients do not have a close relative with type 1 diabetes, meaning the disease can affect any child without a disease history in their family. People with type 1 diabetes must inject the hormone insulin for the rest of their lives because their own immune system is attacking the insulin-producing cells in the islets of their pancreas. Insulin has a vital function, transporting sugar from the blood into the body s cells. The body s own insulin is often the first target of the immune reaction which leads to type 1 diabetes. ....

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Study Shows How Poor Oral Hygiene may Result in Metabolic Syndrome


Study Shows How Poor Oral Hygiene may Result in Metabolic Syndrome
by Colleen Fleiss on 
December 13, 2020 at 10:55 PM
A new mechanism by which periodontal disease may cause diabetes has been discovered by Tokyo Medical and Dental University (TMDU) researchers.
In a new study, researchers from Tokyo Medical and Dental University (TMDU) discovered that infection with Porphyromonas gingivalis, the bacterium causing periodontal disease, causes skeletal muscle metabolic dysfunction, the precursor to metabolic syndrome, by altering the composition of the gut microbiome.
Periodontal bacteria have long been known to cause inflammation within the oral cavity, but also systemically increase inflammatory mediators. As a result, sustained infection with periodontal bacteria can lead to increases in body weight and lead to increased insulin resistance, a hallmark of type 2 diabetes. ....

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