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Nanotechnology Now - Press Release: Getting drugs across the blood-brain barrier using nanoparticles
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Nanotechnology Now - Press Release: Study finds nanomedicine targeting lymph nodes key to triple negative breast cancer treatment: In mice, nanomedicine can remodel the immune microenvironment in lymph node and tumor tissue for long-term remission and lung tumor elimination in this form of metastasized breast cance
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Nanotechnology Now - Press Release: Metasurfaces control polarized light at will: New research unlocks the hidden potential of metasurfaces
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Home > Press > High-speed atomic force microscopy visualizes cell protein factories
Model of translating ribosomes and elongation factors. EF1AGTPaatRNA and EF2 assemble to the ribosomal stalk on the translating ribosome. The translation factor pool contributes to efficient protein synthesis in a crowded intracellular environment.
CREDIT
Proceedings of the National Academy of Sciences
Abstract:
Ribosomes are the complexes of ribonucleoproteins at the heart of protein synthesis in cells. However in the absence of conclusive evidence, how these complexes operate has been open to debate. Now Hirotatsu Imai and Noriyuki Kodera at Kanazawa University, alongside Toshio Uchiumi at Niigata University in Japan, show visualizations of the structural dynamics and factor pooling that take place at ribosome stalk proteins as they build new proteins.
Home > Press > Nanotechnology nanoparticles as weapons against cancer
The amorphous nanoparticles dissolve very efficiently in the cell. Source: von Schirnding et al., Chem 2020
Abstract:
Many chemotherapeutic agents used to treat cancers are associated with side-effects of varying severity, because they are toxic to normal cells as well as malignant tumors. This has motivated the search for effective alternatives to the synthetic pharmaceuticals with which most cancers are currently treated. The use of calcium phosphate and citrate for this purpose has been under discussion for some years now, since they lead to cell death when delivered directly into cells, while their presence in the circulation has little or no toxic effect. The problem consists in finding ways to overcome the mechanisms that control the uptake of these compounds into cells, and ensuring that the compounds act selectively on the cells one wishes to eliminate. Researchers in the Department of Chemistry at LMU