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New Kaposi sarcoma mouse model could be key to drug development

Researchers at UNC Lineberger Comprehensive Cancer Center, after decades of research efforts, have developed a mouse model of Kaposi sarcoma that could be key to the development of new drugs to treat the disease. ....

Dirk Dittmer , University Of North Carolina Health Care , Lineberger Comprehensive Cancer Center , Lineberger Virology Research Program , North Carolina Health , Comprehensive Cancer Center , Cell Host , Virology Research Program , Animal Model , Ouse Model ,

Increased stiffness in aging skin may contribute to higher rates of metastatic skin cancer

Age-related changes that cause the skin to stiffen and become less elastic may also contribute to higher rates of metastatic skin cancer in older people, according to research by investigators from the Johns Hopkins Kimmel Cancer Center. ....

United States , Luo Gu , Gloriae Marino Bravante , Johns Hopkins , Ashani Weeraratna , Yash Chhabra , Alexise Carey , Johns Hopkins Kimmel Cancer Center , Johns Hopkins University School Of Medicine , Duke University , National Institutes Of Health , Melanoma Research Foundation , University Of Pennsylvania , Kimmel Cancer Center , Johns Hopkins Bloomberg School Of Public Health , Johns Hopkins Kimmel Cancer , Nature Aging , Johns Hopkins University School , Melanoma Research , Collum Chair , Molecular Biology , Johns Hopkins Bloomberg School , Public Health , Bloomberg Distinguished , Agrani Dixit , Vania Wang ,

4DMT's one-shot gene therapy cuts anti-VEGF injections in severe wet AMD patients

4DMT Molecular Therapeutics Inc. is looking ahead to phase III as positive data continue to roll out for gene therapy candidate 4D-150 in wet age-related macular degeneration (AMD), with the results from the phase II portion of the phase I/II Prism trial showing the single-shot treatment significantly reduced the need for chronic anti-VEGF injections. ....

Dmt Molecular Therapeutics Inc , 4d Molecular Therapeutics Inc , 4d 150 , Wet Age Related Macular Degeneration , Wet Amd , Gene Therapy , Age Related Macular Degeneration , Central Subfield Thickness , Nd Degeneration 2024 Conference ,

New long-term data for Roche's Vabysmo show sustained

Vabysmo sustained robust drying of retinal fluid, often associated with distorted or blurry vision Up to 60% of people receiving Vabysmo were able to. ....

United Kingdom , France General , United States , Birgit Masjost , Polypoidal Choroidal Vasculopathy , Sabine Borngr , Ramin Tadayoni , Bruno Eschli , Levi Garraway , Loren Kalm , Simon Goldsborough , Kirti Pandey , Sileia Urech , Karsten Kleine , Rebekka Schnell , Head Of Global Product Development , Roche Group , European Medicines Agency , Drug Administration , Us National Institutes Of Health , United Kingdom National Health Service Foundation , European Union , Bascom Palmer Eye Institute , National Eye Institute , European Society Of Retina Specialists , Glob Health ,

YAP and TAZ proteins guide bone development in the womb

A pair of proteins, YAP and TAZ, has been identified as conductors of bone development in the womb and could provide insight into genetic diseases such as osteogenesis imperfecta, known commonly as "brittle bone disease." ....

Julius Wolff , Joel Boerckel , Niamh Nowlan , Joseph Collins , European Research Council , University College Dublin , University Of Pennsylvania School Medicine , University Of Pennsylvania , National Institute Of Arthritis , Pennsylvania School , Developmental Cell , Mckay Orthopaedic Research Laboratory , Perelman School , Penn Bioengineering , Bone Transformation , National Institute , Skin Diseases , Blood Vessels , Osteogenesis Imperfecta ,