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Effectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled…

Objective To assess the clinical and cost effectiveness of conservative management compared with laparoscopic cholecystectomy for the prevention of symptoms and complications in adults with uncomplicated symptomatic gallstone disease.

Design Parallel group, pragmatic randomised, superiority trial.

Setting 20 secondary care centres in the UK.

Participants 434 adults (>18 years) with uncomplicated symptomatic gallstone disease referred to secondary care, assessed for eligibility between August 2016 and November 2019, and randomly assigned (1:1) to receive conservative management or laparoscopic cholecystectomy.

Interventions Conservative management or surgical removal of the gallbladder.

Main outcome measures The primary patient outcome was quality of life, measured by area under the curve, over 18 months using the short form 36 (SF-36) bodily pain domain, with higher scores (range 0-100) indicating better quality of life. Other outcomes included cos ....

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A celebration of ag culture, history – Brandon Sun

Breaking News, Sports, Manitoba, Canada ....

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Mallard Pass Planning Inspectorate will look at concerns

Opponents to a proposed solar farm have started to express their concerns to the Government Planning Inspectorate. ....

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Fate of huge empty Somerset care home revealed

Fate of huge empty Somerset care home revealed
somersetlive.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from somersetlive.co.uk Daily Mail and Mail on Sunday newspapers.

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I ate a Big Mac, double cheeseburger and wrap most days until controversial surgery stopped it

I ate a Big Mac, double cheeseburger and wrap most days until controversial surgery stopped it
walesonline.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from walesonline.co.uk Daily Mail and Mail on Sunday newspapers.

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