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Terminally exhausted T cells may remain competent for transcription, researchers say

During a battle with cancer, T cells can become exhausted and are no longer able to function properly. The early phase of exhaustion can sometimes be reversed with immunotherapy drugs, but once T cells become too exhausted, it had been thought that this state was irreversible. However, new insights from University of Pittsburgh and UPMC researchers suggest that even the most fatigued T cells can be revived. ....

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UPMC: Reinvigorating 'Lost Cause' Exhausted T Cells Could Improve Cancer Immunotherapy | India Education | Latest Education News | Global Educational News

UPMC: Reinvigorating 'Lost Cause' Exhausted T Cells Could Improve Cancer Immunotherapy | India Education | Latest Education News | Global Educational News
indiaeducationdiary.in - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from indiaeducationdiary.in Daily Mail and Mail on Sunday newspapers.

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Cancer Tricks Immune Cells, Immunotherapy Can Take Advantage


Cancer Tricks Immune Cells, Immunotherapy Can Take Advantage
A paper published today in Nature shows how chemicals in the areas surrounding tumors known as the tumor microenvironment subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.
The study was conducted by a team of scientists at the University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center, led by Pitt associate professor of immunology Greg Delgoffe. By disrupting the effect of the tumor microenvironment on immune cells in mice, the researchers were able to shrink tumors, prolong survival and increase sensitivity to immunotherapy. ....

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