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The power and potential of mitochondria transfer

Mitochondria are believed to have originated through an ancient endosymbiotic process in which proteobacteria were captured and co-opted for energy production and cellular metabolism. Mitochondria segregate during cell division and differentiation, with vertical inheritance of mitochondria and the mitochondrial DNA genome from parent to daughter cells. However, an emerging body of literature indicates that some cell types export their mitochondria for delivery to developmentally unrelated cell types, a process called intercellular mitochondria transfer. In this Review, we describe the mechanisms by which mitochondria are transferred between cells and discuss how intercellular mitochondria transfer regulates the physiology and function of various organ systems in health and disease. In particular, we discuss the role of mitochondria transfer in regulating cellular metabolism, cancer, the immune system, maintenance of tissue homeostasis, mitochondrial quality control, wound healing and a ....

South Korea , Acta Neuropathol , Bio Protoc , Cell Biol , Cell Rep , Cells Dev , Death Dis , Death Differ , Pineal Res , Alzheimers Dis , Cancer Res ,

Vaccinex, Inc.'s Phase 2 "SIGNAL" Study to Evaluate Pepinemab Antibody in Huntington's Disease is Published in Nature Medicine along with Detailed Mechanism of Action Study in Journal of Neuroinflammation

Vaccinex, Inc.'s Phase 2 "SIGNAL" Study to Evaluate Pepinemab Antibody in Huntington's Disease is Published in Nature Medicine along with Detailed Mechanism of Action Study in Journal of Neuroinflammation
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John Mullaly , Maurice Zauderer , Exchange Commission , Lifesci Advisors , Vaccinex Inc , Nature Medicine , Chief Executive , Key Findings , Nature Medicine Article , Cognitive Assessment Battery , Problem Behaviors Assessment , Alzheimers Dis , Annual Report , Sci Advisors ,