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Clinical Challenges: Acquired Endocrine Resistance in Breast Cancer


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Most patients with hormone receptor (HR)-positive metastatic breast cancer should receive up to three lines of endocrine therapy as part of guideline-recommended care before starting chemotherapy, said Hope S. Rugo, MD, director of Breast Oncology and Clinical Trials Education at the Helen Diller Family Comprehensive Cancer Center of the University of California San Francisco.
Almost every patient will acquire resistance to endocrine therapy over time, Rugo told
MedPage Today. Some patients will develop resistance in the first year of treatment sometimes within months and some can stay on their first-line endocrine therapy for 7 to 10 years. We don t have a clear understanding of the specific factors that control time to development of acquired resistance, although there are clearly clinical and biologic indications of risk. ....

Alpelisib Piqray , Halle Moore , Cleveland Clinic Taussig Cancer Center , University Of California San Francisco , Helen Diller Family Comprehensive Cancer Center , Breast Oncology , Clinical Trials Education , California San , Cleveland Clinic Taussig Cancer , ஹால் மூர் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் பிரான்சிஸ்கோ , ஹெலன் டில்லர் குடும்பம் விரிவான புற்றுநோய் மையம் , மார்பக புற்றுநோயியல் , மருத்துவ சோதனைகள் கல்வி , கலிஃபோர்னியா சான் ,