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Remdesivir, once only inpatient Covid treatment, could soon become outpatient as antibody supplies wane

Remdesivir, once only inpatient Covid treatment, could soon become outpatient as antibody supplies wane
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Novel immunotherapy boosts long-term stroke recovery in mice


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IMAGE: These images show how regulatory T cells (Treg cells) boost the ability of microglia cells to promote the regeneration of the brain s white matter (right), compared to a sample not.
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Credit: Xiaoming Hu/University of Pittsburgh
PITTSBURGH, May 19, 2021 - Specialized immune cells that accumulate in the brain in the days and weeks after a stroke promote neural functions in mice, pointing to a potential immunotherapy that may boost recovery after the acute injury is over, University of Pittsburgh School of Medicine neurologists found.
The study, published today in the journal
Immunity, demonstrated that a population of specialized immune cells, called regulatory T (Treg) cells, serve as tissue repair engineers to promote functional recovery after stroke. Boosting Treg cells using an antibody complex treatment, originally designed as a therapy after transplantation and for diabetes, improved behavioral and cognitive function ....

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COVID-19 monoclonal antibodies reduce risk of hospitalization and death


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IMAGE: Associate professor in Pitt s Division of Infectious Diseases and director of the UPMC Community Hospital Antimicrobial Stewardship Efforts (CHASE) Program.
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Credit: UPMC
PITTSBURGH, May 17, 2021 - Monoclonal antibodies, a COVID-19 treatment given early after coronavirus infection, cut the risk of hospitalization and death by 60% in those most likely to suffer complications of the disease, according to an analysis of UPMC patients who received the medication compared to similar patients who did not.
UPMC and University of Pittsburgh School of Medicine physician-scientists published the findings today in Open Forum Infectious Diseases, a journal of the Infectious Diseases Society of America. The study involved bamlanivimab, a monoclonal antibody that is now offered only in combination with another monoclonal antibody to further increase its effectiveness a change mandated by the federal government after the study s completion. ....

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