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SARS-CoV-2: how the history of human populati

During the COVID-19 pandemic, the clinical spectrum observed among people infected with SARS-CoV-2 ranged from asymptomatic carriage to death. Researchers at the Institut Pasteur, the CNRS and the Collège de France, in collaboration with researchers around the world , have investigated the extent and drivers of differences in immune responses to SARS-CoV-2 across populations from Central Africa, Western Europe and East Asia. They show that latent cytomegalovirus infection and human genetic factors, driven by natural selection, contribute to population differences in immune response to SARS-CoV-2 and the severity of COVID-19. Understanding the factors underlying such population disparities could help to improve patient management in future epidemics. These results were published on August 9, 2023 in Nature. ....

Rockefeller University , New York , United States , University Hospital , University Of Hong Kong , Hong Kong General , Hong Kong , Central African Republic , France General , Central Africans , Roberto Bruzzone , Yann Aquino , Institut Pasteur , Laurent Abel , Sarah Helene Merkling , Li Ka Shing , Malik Peiris , Jean Laurent Casanova , Mickael Menager , Vincent Bondet , Mary Oneill , Zhi Li , Darragh Duffy , I Hong Kong , Giovanna Barba Spaeth , Francesca Luca ,

SARS-CoV-2: how the history of human populati

SARS-CoV-2: how the history of human populati
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France General , United States , Rockefeller University , New York , Central African Republic , Hong Kong , University Hospital , University Of Hong Kong , Hong Kong General , Central Africans , Maxime Rotival , Yann Aquino , Sophiea Valkenburg , Nikaia Smith , Milena Hasan , Geert Leroux Roels , Mickael Menager , Stefano Pietropaoli , Malik Peiris , Roberto Bruzzone , Lluis Quintana Murci , Francesca Luca , Vincent Bondet , Olivier Schwartz , Gaspard Kerner , Etienne Patin ,

Using paleogenomics to elucidate 10,000 years of immune system evolution

Scientists from the Institut Pasteur, Université Paris Cité, the CNRS and the Collège de France have used paleogenomics to trace 10,000 years of human immune system evolution. They analyzed the genomes of more than 2,800 individuals who lived in Europe over the past ten millennia. They were able to date the increase in frequency of most of the mutations that are advantageous in defending against pathogens to after the Bronze Age, 4,500 years ago. ....

France General , New York , United States , Rockefeller University , Anne Puel , Laurent Abel , Lluis Quintana Murci , Darawan Rinchai , Institut Pasteur , Anna Lena Neehus , Gaspard Kerner , Etienne Patin , Shen Ying Zhang , Nacim Kerrouche , Jonathan Bohlen , Quentin Philippot , Jean Laurent Casanova , Health Unit Universit , France Foundation , Rockefeller University United States , French Foundation For Medical Research , Department Of Pediatrics , Laboratory Of Human Genetics Infectious Diseases , University Paris Cit , Howard Hughes Medical Institute , Paris Cit ,

10,000 Yrs of Immune System Evol. Unveiled via Paleogenomics

10,000 Yrs of Immune System Evol. Unveiled via Paleogenomics
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France General , Lluis Quintana Murci , Institut Pasteur , France Foundation , Rockefeller University United States , Health Unit Universit , French Foundation For Medical Research , Paris Cit , Bronze Age , Cell Genomics , Imagine Institute , Rockefeller University , United States , Iron Age , Middle Ages , Human Evolutionary Genetics Unit , French Foundation , Medical Research , Allianz Institut De France Foundation ,