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100-year-old brain mystery: What does the temporal pole do?

One part of the brain surface, a region called the temporal pole because it is at the very tip of the temporal lobe, could not be linked to a specific function for at least the first 100 years of research on the cortex. Northwestern Medicine scientists have just discovered that this mysterious and seemingly silent surface is actually one of the most colorful regions of the brain. It has critical functions in word comprehension, face recognition and the regulation of behavior. ....

Margaret Flanagan , Allegra Kawles , Ruth Dunbar Davee , Tamar Gefen , Jaiashre Sridhar , Marsel Mesulam , Rudolph Castellani , Pouya Jamshidi , Changiz Geula , Sandra Weintraub , Emily Rogalski , Elena Barbieri , Mesulam Center , Northwestern University Feinberg School Of Medicine , Northwestern University Feinberg School , Northwestern Medicine , Ruth Dunbar Davee Professor , Cognitive Neurology ,

SuperAger brains resist protein tangles that lead to Alzheimer's


Northwestern Now
Findings open new avenue of research in memory loss
Northwestern studies SuperAgers to better understand what is going right in their brains.
A new Northwestern Medicine study showed cognitive SuperAgers have resistance to the development of fibrous tangles in a brain region related to memory and which are known to be markers of Alzheimer’s disease. 
The tangles are made of the tau protein which forms structures that transport nutrients within the nerve cell. These tangles disrupt the cell’s transport system, hampering communication within the neuron and preventing nutrients from performing their particular job within the cell. The end result of tangle formation is cell death. ....

Sandra Weintraub , Beth Makowski Woidan , Margaret Flanagan , Marsel Mesulam , Eileen Bigio , Allegra Kawles , Qinwen Mao , Hui Zhang , Tamar Gefen , Janessa Engelmeyer , Ivan Ayala , Payam Abbassian , Emily Rogalski , Changiz Geula , Northwestern Mesulam Center , Northwestern University Feinberg School Of Medicine , Northwestern Medicine , Northwestern University Feinberg School , Cognitive Neurology , Cortex Pathology , Superior Memory , Cerebral Cortex , National Institute , சாண்ட்ரா வெயிண்ட்ராப் , மார்கரெட் ஃப்ல்யாநகந் , ஹுய் ஜாங் ,