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New approach of nasal vaccine delivery could lead to better vaccines for HIV and Covid

New approach of nasal vaccine delivery could lead to better vaccines for HIV and Covid
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United States , Massachusetts Institute Of Technology , Harvard University , New Iberia , Jane Fontenot , Murillo Silva , Jason Chang , Peng Xiao , Francois Villinger , Josetta Adams , Brittany Hartwell , Sergio Rodriguez Aponte , Dan Barouch , Tyson Moyer , Neil Dalvie , Ruth Ruprecht , Aiquan Chang , Ashley Lemnios , Darrell Irvine , Jingyou Yu , Mariane Melo , Makda Gebre , Laura Maiorino , Kristen Rodrigues , Heikyung Suh , Marble Center ,

Single-dose COVID-19 vaccine effective against variants, study says


In the three months since Johnson & Johnson’s COVID-19 vaccine received emergency use authorization from the U.S. Food and Drug Administration, more than 10 million Americans have received the vaccine, according to the Centers for Disease Control and Prevention. The single-shot viral vector vaccine developed in collaboration with Beth Israel Deaconess Medical Center (BIDMC) immunologist Dan Barouch was authorized for use based on clinical trial data showing strong clinical efficacy against symptomatic COVID-19 in the United States, Latin America and South Africa.
In a new study published in Nature, Barouch, director of BIDMC’s Center for Virology and Vaccine Research, and colleagues report on the antibody and cellular immune responses generated by the Ad26.COV2.S vaccine against the original viral strain and against SARS-CoV-2 variants of concern. The team found that this vaccine induced immune responses against all the viral variants.   ....

United States , South Africa , United Kingdom , Jinyan Liu , Erican Borducchi , Sally Shin , Lisah Tostanoski , Frank Struyf , Caroline Atyeo , Macaya Douoguih , Kathryne Stephenson , Dirk Heerwegh , Katherine Mcmahan , Hanneke Schuitemaker , Dan Barouch , Hannahh Gray , Michelle Lifton , Aiquan Chang , Davidr Martinez , Abishek Chandrashekar , Harlan Robins , Jingyou Yu , Jerald Sadoff , Joseph Nkolola , Brian Kaplan , Catherine Jacob Dolan ,

COVID-19 mRNA Vaccines are Immunogenic in Pregnant and Lactating Women, Including Against Viral Variants


Newswise Boston – Pregnant women with symptomatic COVID-19 have a higher risk of intensive care unit admissions, mechanical ventilation and death compared to non-pregnant reproductive age women. Increases in preterm birth and still birth have also been observed in pregnancies complicated by the viral infection. The Centers for Disease Control and Prevention (CDC) recommended that people who are pregnant may choose to be vaccinated at their own discretion with their healthcare provider. However, pregnant and lactating women were not included in Phase 3 vaccine efficacy trials; thus, data on vaccine safety and immunogenicity in this population is limited.
In a new study from Beth Israel Deaconess Medical Center (BIDMC), specialists in the Department of Obstetrics and Gynecology and the Center for Virology and Vaccine Research evaluated the immunogenicity of COVID-19 mRNA vaccines in pregnant and lactating women who received either the Pfizer or Moderna COVID-19 vaccines. The ....

United States , Jinyan Liu , Erican Borducchi , Lisah Tostanoski , Julia Barrett , Aarong Schmidt , Shivani Patel , Katherine Mcmahan , Owen Sanborn , Esthera Bondzie , Aiquan Chang , Caitlyn Linde , Abishek Chandrashekar , Jingyou Yu , Jessica Ansel , Makda Gebre , Connor Bradshaw , Joseph Nkolola , Ricardo Aguayo , Todd Suscovich , Catherine Jacob Dolan , Tochi Anioke , Jared Feldman , Burroughs Wellcome Fund , Galit Alter Of The Ragon Institute , Ragon Institute ,

COVID-19 mRNA vaccines are immunogenic in pregnant and lactating women


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Boston - Pregnant women with symptomatic COVID-19 have a higher risk of intensive care unit admissions, mechanical ventilation and death compared to non-pregnant reproductive age women. Increases in preterm birth and still birth have also been observed in pregnancies complicated by the viral infection. The Centers for Disease Control and Prevention (CDC) recommended that people who are pregnant may choose to be vaccinated at their own discretion with their healthcare provider. However, pregnant and lactating women were not included in Phase 3 vaccine efficacy trials; thus, data on vaccine safety and immunogenicity in this population is limited.
In a new study from Beth Israel Deaconess Medical Center (BIDMC), specialists in the Department of Obstetrics and Gynecology and the Center for Virology and Vaccine Research evaluated the immunogenicity of COVID-19 mRNA vaccines in pregnant and lactating women who received either the Pfizer or Moderna COVID-19 vaccines. Th ....

United States , Jinyan Liu , Erican Borducchi , Lisah Tostanoski , Julia Barrett , Aarong Schmidt , Shivani Patel , Katherine Mcmahan , Owen Sanborn , Esthera Bondzie , Aiquan Chang , Caitlyn Linde , Abishek Chandrashekar , Jingyou Yu , Jessica Ansel , Makda Gebre , Connor Bradshaw , Joseph Nkolola , Ricardo Aguayo , Todd Suscovich , Catherine Jacob Dolan , Tochi Anioke , Jared Feldman , Centers For Disease , Burroughs Wellcome Fund , Department Of Obstetrics ,