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Study sheds light on how NAD+ levels decline with age in the ovaries, affecting fertility

A woman's fertility normally decreases by her late 30s with reproductive function eventually ceasing at menopause. ....

Lily Ramsey , Eric Verdin , Rosalba Perrone , Buck President , Chief Executive Officer Eric Verdin ,

Comparative genomic analysis between systemic juvenile rheumatoid arthritis and type 1 diabetes

Shared genetic markers and immune system involvement in sJRA and T1D. ....

Khongtham Shutterstock , Nuclear Factor , Scientific Reports , Gene Expression Omnibus , Medical Subject Headings , Mellitus Type , False Discovery Rate , Juvenile Rheumatoid , Juvenile Rheumatoid Arthritis , Rheumatoid Arthritis , Type 1 Diabetes , Cell Cycle , Diabetes Mellitus , Diabetic Ketoacidosis , Ene Expression , Immune System , Juvenile Idiopathic Arthritis , Transcription Factors ,

Urine levels of adenine found to be predictive and causative biomarker of diabetic kidney disease

Urine levels of adenine, a metabolite produced in the kidney, are predictive and a causative biomarker of looming progressive kidney failure in patients with diabetes, a finding that could lead to earlier diagnosis and intervention, researchers from The University of Texas Health Science Center at San Antonio (also called UT Health San Antonio) reported Aug. 24 in the Journal of Clinical Investigation. ....

United States , Lily Ramsey , Kumar Sharma , Department Of Medicine , Teresa Lozano Long School Of Medicine , National Institute Of Diabetes , Ut Health San Antonio , Texas Health Science Center , San Antonio , Teresa Lozano Long School , Chronic Renal Insufficiency Cohort , African American , American Indian , Asian Indians , Kidney Precision Medicine Project , National Institute , Kidney Diseases , Precision Medicine , Kidney Failure , Blood Vessels , Kidney Disease , Precision Medicine , Small Molecules ,

The outcome of invasive S. pyogenes infection is regulated by an interplay between human STING genotype and bacterial NADase activity

The interplay between human STING genotype and bacterial NADase activity. ....

Kateryna Kon Shutterstock , Nature Communications ,

Scientists discover potential cause of genetic mutations linked to Huntington's disease

Scientists have discovered an additional potential cause of the genetic mutations that result in rare conditions such as Huntington's disease (HD). ....

Shouqing Luo , Lily Ramsey , Tsinghua University China , Fudan University , University Of Plymouth , University Of Plymouth United Kingdom , Nature Chemical Biology , United Kingdom , Tsinghua University , Huntington 39s Disease , Neurodegenerative Diseases , Protein Synthesis ,