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Endothelial AHR activity prevents lung barrier disruption in viral infection

Disruption of the lung endothelial–epithelial cell barrier following respiratory virus infection causes cell and fluid accumulation in the air spaces and compromises vital gas exchange function1. Endothelial dysfunction can exacerbate tissue damage2,3, yet it is unclear whether the lung endothelium promotes host resistance against viral pathogens. Here we show that the environmental sensor aryl hydrocarbon receptor (AHR) is highly active in lung endothelial cells and protects against influenza-induced lung vascular leakage. Loss of AHR in endothelia exacerbates lung damage and promotes the infiltration of red blood cells and leukocytes into alveolar air spaces. Moreover, barrier protection is compromised and host susceptibility to secondary bacterial infections is increased when endothelial AHR is missing. AHR engages tissue-protective transcriptional networks in endothelia, including the vasoactive apelin–APJ peptide system4, to prevent a dysplas ....

Apple Academic , Rr Core Team , Stem Cell , Cell Rep , Cell Biol , Cancer Res , Accurate Quantification , Genetic Analysis , Apple Academic Press , Statistical Computing ,

EdiGene to Present getools, a Data Analysis Software Toolkit for Advanced Analytics of DNA and RNA E

BEIJING & CAMBRIDGE, Mass. (BUSINESS WIRE) BEIJING and CAMBRIDGE, MASS. – (May 2, 2022) – EdiGene, Inc., a global, clinical-stage biotechnology company focused on translating gene-editing technologies into transformative therapies for patients with serious genetic diseases and cancer, will present getools (gene ed. ....

United States , United Kingdom , Dong Wei , Xiaomeng Zhang , American Society Of Gene Cell Therapy , Edigene Inc , American Society , Cell Therapy , Annual Meeting , Enables Ultra Fast , Accurate Quantification , Gene Editing Outcomes , Both Bulk , Single Cell Data , Genome Editing Experiments , Wednesday May , Gene Targeting , Gene Correction ,