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Effectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled…

Objective To assess the clinical and cost effectiveness of conservative management compared with laparoscopic cholecystectomy for the prevention of symptoms and complications in adults with uncomplicated symptomatic gallstone disease.

Design Parallel group, pragmatic randomised, superiority trial.

Setting 20 secondary care centres in the UK.

Participants 434 adults (>18 years) with uncomplicated symptomatic gallstone disease referred to secondary care, assessed for eligibility between August 2016 and November 2019, and randomly assigned (1:1) to receive conservative management or laparoscopic cholecystectomy.

Interventions Conservative management or surgical removal of the gallbladder.

Main outcome measures The primary patient outcome was quality of life, measured by area under the curve, over 18 months using the short form 36 (SF-36) bodily pain domain, with higher scores (range 0-100) indicating better quality of life. Other outcomes included cos ....

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Maddie Poppe kicks off 2022 Fayette County Fair

WEST UNION, Iowa (KWWL) – The 2022 Fayette County Fair kicked off Tuesday in West Union, bringing in people from all over the county and surrounding areas. ....

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Youth public speaking contest builds self-esteem, leadership skills that last a lifetime

Youth public speaking contest builds self-esteem, leadership skills that last a lifetime
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