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Variability in Cognitive Decline Raises Questions About Alzheimer's Trials


Jun 9, 2021
Simulation reflected a trial with no treatment effect
Variability in individual cognitive trajectories may be why cognitive results in most Alzheimer’s disease (AD) trials fell within the level of random differences that occur when no treatment effect is expected, a simulation study showed.
“Our simulation reflects a clinical trial in which there is no real treatment effect, and so the 95% range of group differences between our ’placebo’ and ’treatment’ groups reflect the possible range of scores that can be expected when there is no treatment effect,” wrote Roos Jutten, PhD, of Amsterdam UMC in the Netherlands, and co-authors, in ....

United States , Mayo Clinic In Rochester , Noord Holland , Rachel Buckley , Paul Smyth , David Knopman , Roos Jutten , Alzheimer Disease Neuroimaging Initiative , Alzheimer Center Amsterdam , Research Of The Alzheimer Center Amsterdam , Disease Neuroimaging Initiative , Clinical Dementia Rating Sum , Disease Assessment Scale , Mini Mental State Examination , Massachusetts General Hospital , Mayo Clinic , Contributing Writer , Alzheimer Nederland , ஒன்றுபட்டது மாநிலங்களில் , மயோ சிகிச்சையகம் இல் ரோசெஸ்டர் , நூற்த் ஹாலண்ட் , ரேச்சல் பக்லி , பால் ஸ்மித் , முதுமறதி நோய் நியூரோஇமேஜிங் முயற்சி , முதுமறதி மையம் ஆம்ஸ்டர்டாம் , நோய் நியூரோஇமேஜிங் முயற்சி ,