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Novel protein construct prevents lethal COVID-19 in mice Researchers in the United States have developed a novel protein that prevented lethal disease among mice infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19). The team engineered a soluble, short, and dimeric version of the native host cell receptor that is bound by a surface structure on SARS-CoV-2 called spike during the initial stage of the infection process. The team – from the Feinberg School of Medicine in Chicago, the University of Chicago, and Northwestern University in Evanston – suspected that a soluble, truncated version of this membrane-bound receptor – called angiotensin-converting enzyme 2 (ACE2) – would serve as a decoy for SARS-CoV-2 spike binding and potentially neutralize infection.

United statesUniversity of chicagoDaniel batlleSally robertsonFeinberg school of medicineNorthwestern university in evanstonFeinberg schoolNorthwestern universityAngiotensin converting enzyme 2Binding affinityCorona virusCoronavirus disease covid 19In vitroIn vivoMouse modelSars cov 2