E-Mail IMAGE: Senior author and Princess Margaret Scientist Dr. Marianne Koritzinsky's research reveals the potential of targeted therapies to exploit unique metabolic features of pancreatic cancer cells. view more Credit: Visual Services, UHN (Toronto, Friday, May 7, 2021) -- Probing the unique biology of human pancreatic cancer cells in a laboratory has yielded unexpected insights of a weakness that can be used against the cells to kill them. Led by Princess Margaret Cancer Centre (PM) Scientist Dr. Marianne Koritzinsky, researchers showed that about half of patient-derived pancreatic cancer cell lines are highly dependent or "addicted" to the protein peroxiredoxin 4 (PRDX4), as a result of the altered metabolic state of the cancer cell.