one of the inventers of this therapy when it was first brought to the human for mps-1. he helped move this forward for mps-6, which was the second disease that was -- had therapy developed in this group. it was a tremendous breakthrough to be able to give the patients back the missing enzyme. it was a breakthrough of new science, genetics, all of the ability to do gene therapy within cells and make this protein that we can infuse each week. and the future is open. i mean, that's the amazing thing is that isabel is healthy and bright and vigorous and we're within a few years of being able to do gene therapy. trials are ongoing in italy for