firefighters, city workers who did not come to work, they do not want the vaccine. but what about response time in an emergency in new york? and what the mayor is now saying tonight. all eyes on the supreme court tonight, taking up the case of that controversial texas law, banning virtually all abortions in that state. and new signals tonight that some of the conservative justices might have a problem with the way that law was designed. the travel nightmare in the u.s. tonight. american airlines canceling hundreds of flights today, grounding 2,000 flights over the weekend. first southwest, now american. what's going on? with thanksgiving travel just weeks away. tonight, actor alec baldwin breaking his silence on the deadly shooting on that movie set. what the actor is now saying. and the abc news exclusive. tonight, we take you inside madagascar where the u.n. is now warning they're on the brink of the first climate change famine. more than a million people in desperate need of food, facing starvation. and in this pandemic, they are nearly impossible to reach. what we witnessed when we got there. the children who need help. and here in scotland tonight, with so much attention on queen elizabeth and her health, the queen making news just moments ago, in her own words. and good evening tonight from glasgow. we are here as leaders from all over the world converge. president biden among them, for the u.n.'s global summit on climate change. close to 200 countries trying to forge a path forward, to cut greenhouse gas emissions and to slow the earth's and this number tonight, the world has warmed more in the last 29 years than in the past 110 years. president biden delivering a call to action, saying climate change poses an existential threat to human existence as we know it and telling leaders gathered here, let this be the moment when we answer history's call. the president making the case to world leaders that the u.s. will lead on this, after president trump pulled out of the paris climate accord several years back. as proof of biden's commitment, pointing to his domestic agenda back home. $555 billion to fight climate change, create jobs, clean energy, incentives for electric vehicles. but then back home tonight, a major blow to that domestic agenda, at least for now. senator joe manchin saying today he will not be pressured to vote for it, pointing to, quote, shell games and budget gimmicks to pay for it. and right here tonight on climate, our exclusive. the first american network on the ground in southern madagascar where more than a million people are in desperate need of food, facing starvation. mothers holding their children, waiting for help. tonight, the u.n. sounding the alarm, saying madagascar is on the verge of the first famine caused entirely by climate change. and what we saw firsthand. but we begin tonight with the president and abc's chief white house correspondent cecilia vega leading us off right here in scotland. >> reporter: calling it an inflection point in history, president biden today warning leaders that climate change is ravaging the world and destroying people's lives. >> there's no more time to hang back or sit on the fence or argue amongst ourselves. this is the challenge of our collective lifetimes. so, let this be the moment that we answer history's call here in glasgow. >> reporter: wealthy nations like the u.s. are already under fire for not doing more sooner. the president today pointing to his domestic agenda, now working its way through congress. it dedicates $555 billion to fighting climate change, a record. >> the most significant investment to deal with the climate crisis that any advanced nation has made ever. >> reporter: but just three hours later, a major blow from a crucial vote in the ongoing negotiations, moderate senator joe manchin trashing the very framework the president had just promoted. >> what i see are shell games, budget gimmicks that make the real cost of the so-called $1.75 trillion bill estimated to be almost twice that amount. this is a recipe for economic crisis. >> reporter: tonight, the president's agenda now hanging in the balance. house progressives say unless manchin signs off on the framework, they will not vote for a separate bipartisan infrastructure bill. manchin says he won't fold. >> holding that bill hostage is not going to work to get my support of what you want. >> reporter: and the senator sending this blunt message -- >> it's time to pass a bill and quit playing games. >> and cecilia vega with us here in scotland tonight. and, cecilia, president biden was, of course, hoping both bills, the bipartisan infrastructure bill and the second bill with that big focus on climate, would both pass this week, but senator manchin, as we just heard there, making it clear he's not on board yet and he won't be pressured to vote. >> reporter: exactly, and house democrats wanted to vote on this as soon as tomorrow. it is not on the schedule at this point. the leader of the house progressives said today, at this point, it's up to president biden to get joe manchin on board. the white house released a statement, they say they are confident they can get him to support this. no mention of the blow that he delivered today. but, david, the bottom line right now, they still need his vote, and this is not the headline they wanted on this major trip. >> all right, cecilia vega, leading us off tonight, cecilia, thank you. and we're going to turn now to the pandemic. we are now just hours away from what could be the final green light for millions of children when it comes to vaccines. the cdc meets tomorrow on children 5 to 11. and already tonight, millions of pediatric doses shipped out, some arriving at this clinic in washington, d.c., then rushed into those waiting refrigerators. while in new york city tonight, the vaccine mandate for city workers taking effect and thousands of frontline workers defiant, staying home instead of getting vaccinated. 18 fire companies out of service because of sick calls. but tonight, the mayor now vowing emergency response time is normal and saying the mandate is working. here's abc's erielle reshef tonight. >> reporter: tonight, new york city enforcing its new vaccine mandate by putting 9,000 unvaccinated city workers on unpaid leave. 18 fire companies are out of service after a surge in sick calls. but despite opposition to mandates, the mayor reporting no city services have been disrupted. >> response times normal for fire, ems, nypd. this mandate was the right thing to do and the proof is in the pudding. we now see it worked. >> reporter: since friday's deadline, the vaccination rate among city workers climbing to 91%. it comes just a day before the cdc could sign off on the pfizer vaccine for 5 to 11-year-olds. the first wave of pediatric doses arriving at this clinic in washington, d.c., where they are unpacked and stored in a refrigerator until doctors get that green light. >> parents should feel comforted not just that their children will be protected, but that this vaccine has gone through the necessary and rigorous evaluation that ensures the vaccine is safe and highly effective. >> reporter: and, david, tonight, moderna now says that the fda is requiring more time to study whether its vaccine increased the risk of that rare heart inflammation called myocarditis in kids ages 12 to 17. it comes after reports of some mild cases in boys and young men that resolved with treatment. david? >> all right, erielle reshef tonight. erielle, thank you. and all eyes on the supreme court tonight, now hearing oral arguments on that controversial new texas law that has banned nearly all abortions in that state. and tonight, some of the questions from the justices seeming to signal tonight that some of the conservative justices might have a problem with the way the law was designed. abc's rachel scott tonight at the supreme court. >> roe v. wade has got to go. >> my body, my choice! >> reporter: today, as protesters rallied outside the supreme court, inside, for the first time, a majority of justices signaled they are not comfortable with the new texas law. the law bans abortions as early as six weeks into pregnancy. today, the justices zeroing in on the unusual way it's enforced. it does not rely on police or state officials, instead, it empowers private citizens to sue anyone who helps a woman get unlawful abortion, from the doctors who perform them to uber drivers who take a woman to the clinic. >> there's a loophole that's been exploited here or used here. >> reporter: conservative justices brett kavanaugh and amy coney barrett, who weeks ago refused to block the law, today questioned whether that loophole should be closed. liberal justice elena kagan saying the law invites other states to deprive citizens of constitutional rights they object to. >> essentially we would be like, you know, we are open, you are open for business. there's nothing the supreme court can do about it. guns, same-sex marriage, religious rights, whatever you don't like, go ahead. >> reporter: david, it's unclear tonight how soon the supreme court will hand down a decision, but a majority of the justices on the bench today signaled that abortion providers have a strong case to ask federal courts to put that texas law on hold. david? >> all right, rachel scott at the court tonight. rachel, thank you. now to the travel chaos across the u.s. more than 2,000 flights canceled over the weekend. hundreds more grounded today. american airlines hit especially hard, and it comes after the mess with southwest airlines weeks ago. so, what's going on with the thanksgiving travel just weeks away now. here's abc's marcus moore tonight. >> reporter: tonight, american airlines, the latest carrier to come down with a cascade of cancellations. >> cancel my flight? i got to go home. >> reporter: more than 300 friday, more than 500 saturday and eclipsing 1,000, nearly 1 in 5 flights canceled on sunday and hundreds more today. and the ripple effect was felt at airports across the country including here in kansas city, where over the weekend some travelers watched as those frustrating delays got longer and longer. american blaming high winds thursday at their largest hub, dallas/ft. worth airport. writing in a note to employees, quote, we could only use two runways instead of the usual five. the other problem, a lack of staff. post-pandemic, airlines are racing to rehire and retrain thousands of workers and the timing. >> when bad weather hits an airline at the end of the month, the problems are exacerbated because often crews are out of the legal amount of time they're allowed to work. >> reporter: david, american said that 1,800 of its workers were set to return from leave today and that this situation should stabilize by midweek. david? >> marcus moore with us tonight. marcus, thank you. we're going to turn now to the abc news exclusive inside madagascar. tonight, the u.n. warning of that first famine driven entirely by climate change. we have covered hunger and famine for many years on this broadcast, but so often conflict, war, terror are the driving forces behind it. but tonight, the u.n. says this is climate. more than a million people facing hunger and starvation in southern madagascar, and we boarded a small plane with the world food program to get to the south and what we witnessed when we got there. we are allowed on board one of the only flights into southern madagascar, a region so remote, few have made it in during this global pandemic. where right now the u.n. warns of another catastrophe. through the window, a hint of what we'll witness. the scorched landscape. we land where the world food program is waiting for us. the trucks disappearing in the wind-driven sand. five years of drought here, and we find the village where we've been told mothers have now brought their children for help. the families waiting outside. mothers holding their children. they are waiting to learn what the numbers will soon reveal. the baby boy dangling from the scale where the children are weighed. were you worried about your little boy? >> yeah, she was worried because this child is malnourished. >> measuring their arms with small pieces of color-coded tape. that's what the yellow tells you? >> the yellow tells you that this child is suffering from moderate acute malnutrition. david, this is a new admission. this child is the first time today. >> another child in need. >> they are checking if any edema, and they're going to press three seconds on both feet. >> they are looking for swelling in the tissue, another sign of malnutrition, and they find it. we witness the urgency, the cries. the boy being weighed in a red bucket. the quiet little girl waiting. and the baby, they write her weight on her arm. this little girl, angelica, who is 4. they wrap the tape around her tiny arm, the small window revealing the red. >> once again, a severely malnourished child. >> showing her stomach to the aid workers. she is given fluids for dehydration and an antibiotic. unsure of its taste. in so many of these villages, we're told, there has been no proper rain in years. rising temperatures and violent sandstorms now define their climate. the land now made up of sand dunes. and at the top of this hill, we see the villagers, waiting to tell us what they're living through. what have you seen change over the last couple of years? >> we have seen everything change. our life is getting worse. >> we see the cracked earth for miles. what are we witnessing right now as far as climate? >> it's something really new. it's a change in the landscape. having sandstorms in this kind of landscape is not something usual and having the effects of sandstorms shows that nature is changing, the environment is changing, and the climate change is affecting this area more than the rest of madagascar. >> rainfall patterns have grown erratic. and scientists say temperatures in the region are rising at double the global rate. >> it's not just this year, it's building up, you know? it's year after year that the rains are less and that people have less and less food to eat. >> we witness the families here who spend an entire day hoping to find water. and we go to find it, too. this was once one of the main rivers here. i'm standing in what was once the mandrare river, more than 160 miles long. a year ago, i would have been standing in water. now, all that remains is sand and the few pockets of water, they bring in livestock from all over to get any water they can find. we meet a mother, digging several feet down to find water. how far did you come to get water? >> three hours. >> three hours to come get water. they scoop it up one cup at a time. and this mother takes a break to drink it. and we witness what they turn to when there is no more food to eat. in some cases locusts, insects and red cactus. this mother shows us what little she has to prepare for dinner. >> this is what we're going to eat this evening. the leaves of cactus. >> the leaves of cactus. she then tells us, she just lost her husband to starvation. >> he died because there was nothing to eat. >> she takes us to where she now lives with her children. >> it's so hard for us to face the drought. >> and she shows us all that's left to eat. so this is what you cook. she tries to get the needles off. peel the pins off? we approach maroafo where their emergency has just been discovered. we pull in and immediately we see the crowds. and we are told this is the first time anyone has brought this village food. this is the first time -- >> this is the first time they receive the food. >> they were in desperate need, but nobody knew. >> no, no. >> and around the corner, this little girl named sambevoome-ne. and her eyes. >> she's more than 5 years old. >> she's older than 5? she touches her stomach. and tells us it hurts. >> she said that she has pain in her stomach. >> there is pain from the red cactus. >> yeah.this is an emergency.- it's clearly an emergency. >> you can see it here in the faces of the children, so many of them already severely malnourished. and we haven't even reached the lean season, that's when they would plant with the hope that there might be some sign of rain in the coming months. but it's a slim hope and these children are already in trouble. >> we're providing them only with 15 days worth of food. >> 15 days. >> 15 days, but they need one month, right? they're human beings like you and me, we can't eat every other day. >> everywhere we look, we see the strength of the children here. the unexpected smile. the little girl in the blue dress. and the boy we noticed quietly capturing the drops of water from a jug in his hand. not letting a drop go to waste. the children are resilient here but not immune from a worsening climate. and this number tonight, the world carbon project saying the people of madagascar contribute .01% of carbon emissions worldwide, so little, and yet they are truly paying the price. if you would like to learn more, if you would like to help, you can go to our home page, abcnews.com. we will continue our reporting later tonight. we hope you will watch or set your dvr for a special edition of "nightline" right after jimmy kimmel. when we come back here tonight, the other news this evening. actor alec baldwin now breaking his silence on the deadly shooting on that movie set. and what the actor is now saying. 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