1. Combination therapy of empagliflozin and citalopram reduced symptom severity in patients with major depressive disorder. 2. This average reduction in symptom severity was statistically significant over time in comparison to the reduction of symptoms seen in the placebo-citalopram group. Evidence Rating Level: 1 (Excellent) Antidepressants like selective serotonin reuptake inhibitors (SSRIs) are presently first-line