ஹாரேஸியோ கப்ரல் News Today : Breaking News, Live Updates & Top Stories | Vimarsana
Alunos voltam às escolas em Rolândia com nova realidade
folhadelondrina.com.br - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from folhadelondrina.com.br Daily Mail and Mail on Sunday newspapers.
Efficacy of polymeric nano-micelles depends on expression level of c-Myc
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.
It is known that c-Myc is involved in cancer cell proliferation and angiogenesis and changes the cell cycle, suppresses normal cell differentiation, and promotes cancer metastasis. It is a typical proto-oncogene that regulates many genes related to growth factors and is known to be involved in developing of many cancers, such as chromosomal translocation in Burkitt lymphoma. Therefore, drug discovery research is being conducted worldwide as an anticancer drug targeting this transcription factor that can directly attack cancer stem cells. However, since embryonic lethality occurs in c-Myc knockout mice, c-Myc is considered as an essential gene for living cells, and selective delivery to cancer tissues is an important key to developing its inhibitors. Besides, c-Myc is also known as a factor necessary for the initial induction of iPS cells. In the future this inhibition can be expected to be applied as a technology that can also be used to suppress iPS cell-derived carcinogenesis.