Yasunobu Okugawa earns first win as Swallows beat Carp Sorry, but your browser needs Javascript to use this site. If you re not sure how to activate it, please refer to this site: https://www.enable-javascript.com/
KYODO Apr 9, 2021
Hard-throwing rookie Yasunobu Okugawa overcame a four-run first inning and a long rain delay to earn his first pro victory as the Yakult Swallows came from behind to beat the Hiroshima Carp 11-7 in the Central League on Thursday.
The 19-year-old Okugawa (1-1), one of the stars of Japan’s 2019 pro draft, allowed five-straight hits in the top of the first at Tokyo’s Jingu Stadium to put his team in a four-run hole, but one his teammates quickly erased.
Efficacy of polymeric nano-micelles depends on expression level of c-Myc news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.
It is known that c-Myc is involved in cancer cell proliferation and angiogenesis and changes the cell cycle, suppresses normal cell differentiation, and promotes cancer metastasis. It is a typical proto-oncogene that regulates many genes related to growth factors and is known to be involved in developing of many cancers, such as chromosomal translocation in Burkitt lymphoma. Therefore, drug discovery research is being conducted worldwide as an anticancer drug targeting this transcription factor that can directly attack cancer stem cells. However, since embryonic lethality occurs in c-Myc knockout mice, c-Myc is considered as an essential gene for living cells, and selective delivery to cancer tissues is an important key to developing its inhibitors. Besides, c-Myc is also known as a factor necessary for the initial induction of iPS cells. In the future this inhibition can be expected to be applied as a technology that can also be used to suppress iPS cell-derived carcinogenesis.