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CRN: ‘This is not the final word on NAC’ While Amazon moves ahead with removing NAC-containing dietary supplements from its website, the FDA’s Office of Dietary Supplement Programs (ODSP) acknowledges that it is still reviewing the information around the ingredient. NAC (N-acetyl-L-cysteine) is a derivative of the amino acid L-cysteine and is a precursor of the cellular antioxidant glutathione. The ingredient was first approved as an inhaled mucolytic drug in 1963. At present it is used in emergency rooms as a treatment in cases of acetaminophen poisoning to prevent severe liver damage.  Despite its early use as a respiratory medication, the ingredient has been widely used for many years in finished dietary supplements, frequently as a standalone product.  A search of the Dietary Supplement Label Database from the NIH’s Office of Dietary Supplements​ yields 1,468 products containing NAC (database accessed May 7, 2021), including some of the

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