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Reversing How Proteins Accumulate in Wrong Parts of Brain Cells

Reversing How Proteins Accumulate in Wrong Parts of Brain Cells
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Giulia tyzackJacob neevesRickie pataniJasmine harleyNational hospital for neurologyUniversity college londonQueen square institute of neurologyBrain communicationsFrancis crick instituteNeurodegeneration laboratoryHuman stem cellsSquare instituteNational hospitalரிக்கி படானிதேசிய மருத்துவமனை க்கு நரம்பியல்பல்கலைக்கழகம் கல்லூரி லண்டன்

Scientists reverse a key hallmark of motor neurone disease in the laboratory

Scientists reverse a key hallmark of motor neurone disease in the laboratory
scienceblog.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from scienceblog.com Daily Mail and Mail on Sunday newspapers.

Giulia tyzackJacob neevesRickie pataniJasmine harleyNational hospital for neurologyQueen square institute of neurologyBrain communicationsFrancis crick instituteNeurodegeneration laboratoryHuman stem cellsSquare instituteNational hospitalரிக்கி படானிதேசிய மருத்துவமனை க்கு நரம்பியல்ராணி சதுரம் நிறுவனம் ஆஃப் நரம்பியல்மூளை தகவல்தொடர்புகள்

Researchers reveal process behind harmful glial cell change in motor neurone disease

E-Mail Scientists at the Francis Crick Institute and UCL have identified the trigger of a key cellular change in amyotrophic lateral sclerosis (ALS), a type of motor neurone disease. The findings could help develop new treatments for many neurological diseases with the same change, including Parkinson s and Alzheimer s. When the nervous system is injured, diseased or infected, star-shaped cells, called astrocytes, undergo reactive changes in their behaviour. Whilst some of these reactive astrocytes become protective, others become harmful and damage surrounding motor neurons. Reactive astrocytes are observed in various neurodegenerative diseases including ALS, but there is a lack of understanding about what causes astrocytes to undergo this change.

United kingdomCity ofOliver ziffRickie pataniUniversity college londonKing college londonQueen square institute of neurologyNucleic acids researchNational hospital for neurologyImperial college londonCancer research united kingdomResearch councilFrancis crick instituteSquare instituteNational hospitalMedical research council

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis Scientists at the Francis Crick Institute and UCL have identified the trigger of a key cellular change in amyotrophic lateral sclerosis (ALS), a type of motor neurons disease. The findings could help develop new treatments for many neurological diseases with the same change, including Parkinson s and Alzheimer s. When the nervous system is injured, diseased or infected, star-shaped cells, called astrocytes, undergo reactive changes in their behavior. Whilst some of these reactive astrocytes become protective, others become harmful and damage surrounding motor neurons. Reactive astrocytes are observed in various neurodegenerative diseases including ALS, but there is a lack of understanding about what causes astrocytes to undergo this change.

Oliver ziffRickie pataniEmily hendersonNational hospital for neurologyQueen square institute of neurologyGroup leaderNucleic acids researchFrancis crick instituteSenior study authorQueen square instituteConsultant neurologistNational hospitalSquare instituteMotor neurone diseaseAmyotrophic lateral sclerosisGenetic information