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 E-Mail BOSTON - Researchers at Massachusetts General Hospital (MGH) have uncovered new clues that add to the growing understanding of how female mammals, including humans, silence one X chromosome. Their new study, published in Molecular Cell, demonstrates how certain proteins alter the architecture of the X chromosome, which contributes to its inactivation. Better understanding of X chromosome inactivation could help scientists figure out how to reverse the process, potentially leading to cures for devastating genetic disorders. Female mammals have two copies of the X chromosome in all of their cells. Each X chromosome contains many genes, but only one of the pair can be active; if both X chromosomes expressed genes, the cell couldn t survive. To prevent both X chromosomes from being active, female mammals have a mechanism that inactivates one of them during development. X chromosome inactivation is orchestrated by a noncoding form of RNA called Xist, which silences genes

United statesJeannie leeAndrea krizDepartment of molecular biologyLee laboratoryGenetics at harvard medical schoolMassachusetts general hospitalMolecular cellMolecular biologyHarvard medicalSex linked conditionsஒன்றுபட்டது மாநிலங்களில்ஜீனி லீதுறை ஆஃப் மூலக்கூறு உயிரியல்லீ ஆய்வகம்ஜெநெடிக்ஸ் இல் ஹார்வர்ட் மருத்துவ பள்ளி