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BOSTON - Researchers at Massachusetts General Hospital (MGH) have uncovered new clues that add to the growing understanding of how female mammals, including humans, silence one X chromosome. Their new study, published in
Molecular Cell, demonstrates how certain proteins alter the architecture of the X chromosome, which contributes to its inactivation. Better understanding of X chromosome inactivation could help scientists figure out how to reverse the process, potentially leading to cures for devastating genetic disorders.
Female mammals have two copies of the X chromosome in all of their cells. Each X chromosome contains many genes, but only one of the pair can be active; if both X chromosomes expressed genes, the cell couldn t survive. To prevent both X chromosomes from being active, female mammals have a mechanism that inactivates one of them during development. X chromosome inactivation is orchestrated by a noncoding form of RNA called Xist, which silences genes
Take a hike! How walking gear got a high fashion makeover Naomi May
Our collective hunger for comfort has never been more apparent than it is now.
Month ten of the New Normal and trousers have been swapped for trackies, our heels replaced with house shoes and our poplin shirts traded for pyjamas. Times have changed. And now we’re ready to take it one step further, by embracing outdoor apparel. No, not your camel coat, your tan trench, or your box-fresh sneakers, but hiking boots! Puffer jackets! Hell, even fleeces!
Once the preserve of geography teachers, the UK’s outdoor industry (which includes apparel and footwear) was valued at £1.5 billion in 2020 and has been predicted to grow by a further £2.8 billion by 2024.
When it comes to resolutions, setting a high bar is admirable, but can have toxic consequences if you fall at the first hurdle. In order to get over that 4 January bump, resolutions need to be realistic. Let’s be kind to ourselves this year and set some 2021 fashion resolutions that are fun to focus on and do a little bit of good at the same time.
We’ve all known for some time that we should be shopping more sensibly, making the most of our wardrobe and truly considering the footprint and supply chain of our new purchases, but there is no time like the present to actually implement these shifts in mindset. Similarly, why not use 2021 to push yourself out of your comfort zone, sartorially speaking?
How leggings became the defining clothing item of 2020
Today’s John Lewis report showed sales of leggings rose by a whopping 1,303 percent this year
21 December 2020 • 12:44pm
Leggings by: Lucas Hugh; The Girlfriend Collective and Vaara
Last year, a furore erupted in the United States when a university newspaper columnist suggested that female students who wore leggings to lectures were making it impossible for young men to concentrate. Hundreds of women gathered to protest, wearing - what else? - the sort of figure-sculpting leggings we’ve all become accustomed to putting on for a lot more than just exercise.
Showing how much the world can change in a year, today s annual John Lewis report - which was released this morning - showed that sales of leggings rose by 1,303 percent compared with 2019, as we began to attend work meetings, teach our children and socialise in stretchwear. One woman even learned she had been elected Vice President in a pair (VP-Elect Kam