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AbbVie ditches late-stage eye drug license, collab with Molecular Partners

AbbVie ditches late-stage eye drug license, collab with Molecular Partners
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Molecular Partners Reports Continued Progress of Ensovibep Global Clinical Program; Positive in

Press release content from Globe Newswire. The AP news staff was not involved in its creation. Molecular Partners Reports Continued Progress of Ensovibep Global Clinical Program; Positive in . Molecular PartnersJuly 8, 2021 GMT Ensovibep maintains potency in an in vitro assay and demonstrated full inhibition of all newly emerging known variants of concern, including the Delta variants of concern EMPATHY Phase 2/3 trial enrolling ambulatory patients in 5 countries with more countries to be added in the coming months, with interim data expected in H2 2021 and full topline data expected in early 2022 ACTIV-3, a Phase 3 trial enrolling hospitalized patients across 4 countries with more countries expected to be added in the coming months, with topline data expected in 2022

Molecular Partners Reports Continued Progress of Ensovibep Global Clinical Program; Positive in vitro Data Demonstrating Maintained Inhibition of Delta and All Other Known Variants of Concern of SARS-CoV-2

Home / Top News / Molecular Partners Reports Continued Progress of Ensovibep Global Clinical Program; Positive in vitro Data Demonstrating Maintained Inhibition of Delta and All Other Known Variants of Concern of SARS-CoV-2 Molecular Partners Reports Continued Progress of Ensovibep Global Clinical Program; Positive in vitro Data Demonstrating Maintained Inhibition of Delta and All Other Known Variants of Concern of SARS-CoV-2 Ensovibep maintains potency in an in vitro assay and demonstrated full inhibition of all newly emerging known variants of concern, including the Delta variants of concern EMPATHY Phase 2/3 trial enrolling ambulatory patients in 5 countries with more countries to be added in the coming months, with interim data expected in H2 2021 and full topline data expected in early 2022

Novartis launches trial to test ensovibep as COVID treatment

The EMPHATHY clinical trial will enroll patients with COVID-19 to test the drug’s effectiveness in preventing worsening of symptoms and hospitalization. Novartis and Molecular Partners have announced the start of their EMPATHY Phase II/III study to explore the use of its DARPin (designed ankyrin repeat proteins) therapeutic candidate ensovibep (MP0420) for the treatment of COVID-19. Novartis reportedly will run the trial program, with Molecular Partners serving as sponsor. The EMPATHY clinical trial program is intended to investigate the safety and efficacy of ensovibep in COVID-19 in the early stages of infection, with the goal of worsening symptoms and hospitalization. According to the companies, the study will enroll 400 patients in Phase II to determine a dose with optimal safety and activity; initial results are expected in August 2021.

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