Researchers Invent New Gene Editing Tool March 3, 2021
Specially engineered guide RNA molecules called “proGuides” may allow scientists to program sequential gene edits over time.
Researchers from the University of Illinois Chicago (UIC) have discovered a new gene editing technique that allows for the programming of sequential cuts or edits over time.
The new process developed by UIC s Bradley Merrill, lead author of the paper published in Molecular Cell, involves using special molecules called guide RNA that ferry the Cas9 enzyme within the cell and determine the precise DNA sequence at which Cas9 will cut. They call their specially engineered guide RNA molecules proGuides, and the molecules allow for the programmed sequential editing of DNA using Cas9.
New gene-editing tool enables programming of sequential cuts over time
Researchers from the University of Illinois Chicago have discovered a new gene-editing technique that allows for the programming of sequential cuts or edits over time.
CRISPR is a gene-editing tool that allows scientists to change the DNA sequences in cells and sometimes add a desired sequence or genes. CRISPR uses an enzyme called Cas9 that acts like scissors to make a cut precisely at a desired location in the DNA. Once a cut is made, the ways in which cells repair the DNA break can be influenced to result in different changes or edits to the DNA sequence.
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Researchers from the University of Illinois Chicago have discovered a new gene-editing technique that allows for the programming of sequential cuts or edits over time.
CRISPR is a gene-editing tool that allows scientists to change the DNA sequences in cells and sometimes add a desired sequence or genes. CRISPR uses an enzyme called Cas9 that acts like scissors to make a cut precisely at a desired location in the DNA. Once a cut is made, the ways in which cells repair the DNA break can be influenced to result in different changes or edits to the DNA sequence.
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