This figure presents serum binding and functional antibody responses following COVID-19 vaccination and SARS-CoV-2 infection among women 45 years or younger.
A and B, Each panel compares vaccine antibody responses at 2 through 8 weeks after the second dose to nonpregnant and pregnant women who were unvaccinated and infected. Thirteen women (7 nonpregnant, 4 pregnant, and 2 lactating) who had baseline samples collected within 7 days of their first vaccine dose were selected based on the earliest sample availability and were analyzed as a negative assay control.
C, D, and E, Systems serology was used to quantify spike-specific antibody–dependent neutrophil phagocytosis (ADNP), antibody–dependent complement deposition (ADCD), and antibody–dependent monocyte cellular phagocytosis (ADCP).
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Boston - Pregnant women with symptomatic COVID-19 have a higher risk of intensive care unit admissions, mechanical ventilation and death compared to non-pregnant reproductive age women. Increases in preterm birth and still birth have also been observed in pregnancies complicated by the viral infection. The Centers for Disease Control and Prevention (CDC) recommended that people who are pregnant may choose to be vaccinated at their own discretion with their healthcare provider. However, pregnant and lactating women were not included in Phase 3 vaccine efficacy trials; thus, data on vaccine safety and immunogenicity in this population is limited.
In a new study from Beth Israel Deaconess Medical Center (BIDMC), specialists in the Department of Obstetrics and Gynecology and the Center for Virology and Vaccine Research evaluated the immunogenicity of COVID-19 mRNA vaccines in pregnant and lactating women who received either the Pfizer or Moderna COVID-19 vaccines. The researc
Gene Editing Expands to New Types of Immune Cells
Gladstone researchers fine-tuned CRISPR-Cas9 genome editing to work on human immune cells called monocytes
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SAN FRANCISCO, May 11, 2021 /PRNewswire/ In the decade since the advent of CRISPR-Cas9 gene editing, researchers have used the technology to delete or change genes in a growing number of cell types. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) have added human monocytes white blood cells that play key roles in the immune system to that list.
A team of scientists at Gladstone Institutes and UC San Francisco led by Alex Marson (left) and Nevan Krogan (right) fine-tuned CRISPR-Cas9 genome editing to help understand how the human immune system fights viruses and microbes.
Research Article
Associations of treated and untreated human papillomavirus infection with preterm delivery and neonatal mortality: A Swedish population-based study
Johanna Wiik , Roles Data curation, Formal analysis, Methodology, Supervision, Writing – review & editing
Affiliations Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden, Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Roles Conceptualization, Methodology, Writing – review & editing
Affiliations Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Gothenburg, Sweden, Regional Cancer Centre West, Region Västra Götaland, Gothenburg, Sweden
Stanford researchers identify blood markers that indicate labor is approaching stanford.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from stanford.edu Daily Mail and Mail on Sunday newspapers.