New technique for studying cancer mutations - approaches for future therapies miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
Whether bacteria are resistant to antibiotics is often decided at the cell membrane. This is where antibiotics can be blocked on their way into the cell interior or catapulted from the inside to the outside. Macrocyclic peptides, a novel class of antibiotics, bioactive cytotoxins and inhibitors, shed light on how this transport process occurs at the membrane, how it is influenced and how it can be used to circumvent the resistance of a malignantly transformed cell.
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IMAGE: Scientists Martin Hengesbach (left) und Andreas Schlundt at the nuclear magnetic resonance (NMR) spectrometre at Goethe-University Frankfurt, Germany. view more
Credit: Uwe Dettmar for Goethe-University Frankfurt, Germany
FRANKFURT. When the SARS-CoV-2 virus mutates, this initially only means that there is a change in its genetic blueprint. The mutation may lead, for example, to an amino acid being exchanged at a particular site in a viral protein. In order to quickly assess the effect of this change, a three-dimensional image of the viral protein is extremely helpful. This is because it shows whether the switch in amino acid has consequences for the function of the protein - or for the interaction with a potential drug or antibody.
T
he wooly mammoth (
Mammuthus primigenius) is an iconic animal, like the saber tooth tiger or dire wolf, from a time in human history when our position at the top of the global food chain was decidedly not assured (and being something s prey was not limited to just other humans). Perhaps this is a reason that resurrection of mammoths using Jurassic Park-like technology has some currency and appeal (
but see
How to Clone a Mammoth for reasons why this may not be such a good idea). Perhaps paradoxically, the mammoth arose in Africa 5 million years ago and like its (very) distant