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Cryo-EM reveals structure of key enzyme involved in protein production

Transfer RNAs (tRNAs) are among the most common types of RNA in a cell and are indispensable for protein production in all known organisms.

Samoil sekulovskiDanielle ellisSimon trowitzschJulius maximilians universityInstitute of biochemistryGoethe universityInstitute of biochemistry at goethe universityInstitute of biochemistry at goethe university frankfurtGoethe university frankfurtStructural biologyGenetic informationPontocerebellar hypoplasia

Structural biology: Molecular scissors caught in the act: Structure of an enzyme crucial for tRNA maturation sheds light on cause of neurodegenerative disorders

Structural biology: Molecular scissors caught in the act: Structure of an enzyme crucial for tRNA maturation sheds light on cause of neurodegenerative disorders
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Samoil sekulovskiSimon trowitzschInstitute of biochemistry at goethe universityInstitute of biochemistry at goethe university frankfurtJulius maximilians universityGoethe university frankfurtGoethe university

Structural biology: Molecular scissors caught in act

Structural biology: Molecular scissors caught in act
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Lukas suSamoil sekulovskiLukass stelzlSimon trowitzschInstitute of biochemistry at goethe university frankfurtJohannes gutenberg university mainzGoethe universityResearchers at goethe university frankfurtInstitute of biochemistry at goethe universityTrowitzsch labJulius maximilians universityGoethe university frankfurtRobert tampMolecular biologyJinwei zhang

Molecular scissors caught in the act: Describing the function of tRNA splicing endonuclease TSEN based on its structure

Molecular scissors caught in the act: Describing the function of tRNA splicing endonuclease TSEN based on its structure
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Samoil sekulovskiJinwei zhangAnitak hopperSimon trowitzschInstitute of biochemistry at goethe universityGoethe universityJulius maximilians universityInstitute of biochemistry at goethe university frankfurtTrowitzsch labResearchers at goethe university frankfurtJohannes gutenberg university mainzGoethe university frankfurtNature structuralMolecular biology

In slow motion against antibiotic resistance

Whether bacteria are resistant to antibiotics is often decided at the cell membrane. This is where antibiotics can be blocked on their way into the cell interior or catapulted from the inside to the outside. Macrocyclic peptides, a novel class of antibiotics, bioactive cytotoxins and inhibitors, shed light on how this transport process occurs at the membrane, how it is influenced and how it can be used to circumvent the resistance of a malignantly transformed cell.

Institute for biochemistryInstitute of biochemistry at goethe universityScientists at goethe universityGoethe universityUniversity of tokyoCollaborative research centreGoethe university frankfurtRobert tampCell biologyMedicine healthநிறுவனம் க்கு உயிர் வேதியியல்விஞ்ஞானிகள் இல் கோதீ பல்கலைக்கழகம்கோதீ பல்கலைக்கழகம்பல்கலைக்கழகம் ஆஃப் டோக்கியோகூட்டு ஆராய்ச்சி மையம்கோதீ பல்கலைக்கழகம் பிராங்க்ஃபர்ட்