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Audio: An Alzheimer s Drug May Boost Cognition In People With Fragile X Syndrome

An experimental drug intended for Alzheimer s patients seems to improve both language and learning in adults with Fragile X syndrome. The drug, called BPN14770, increased cognitive scores by about 10% in 30 adult males after 12 weeks, a team reports in the journal Nature Medicine. That is enough to change the lives of many people with Fragile X, says Mark Gurney, CEO of Tetra Therapeutics, developer of the medicine. People with Fragile X with an IQ of 40 are typically living with their parents or in an institutional setting, Gurney says. With an IQ of 50, in some cases they re able to ride the bus, they re able to hold a job with some assistance and they re able to function better in their community.

Encouraging Results For Alzheimer s Drug Repurposed For Fragile X Syndrome : Shots

Fragile X syndrome involves changes in the X chromosome, as pictured in the four columns of chromosomes starting on the left. The fifth column, on the far right, shows two normal X chromosomes. Richard J. Green/Science Source An experimental drug intended for Alzheimer s patients seems to improve both language and learning in adults with Fragile X syndrome. The drug, called BPN14770, increased cognitive scores by about 10% in 30 adult males after 12 weeks, a team reports in the journal Nature Medicine. That is enough to change the lives of many people with Fragile X, says Mark Gurney, CEO of Tetra Therapeutics, developer of the medicine.

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