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New therapy to mitigate fragile X syndrome may be on the horizon

An antisense therapy developed by Joel D. Richter, PhD, Sneha Shah, PhD, and Jonathan K. Watts, PhD, at UMass Chan Medical School and Elizabeth Berry-Kravis, MD, PhD, at RUSH University Medical Center, restores production of the protein FMRP in cell samples taken from patients with fragile X syndrome.

Huseyin mehmetElizabeth berry kravisMichael tranfagliaUmass chanDanielle ellisSneha shahArthurf koskinasJonathank wattsJoeld richterUniversity medical centerBusiness developmentSimons foundation for autism researchProceedings of the national academy sciencesNational institutes of healthUmass chan medical schoolResearch foundation

Antisense therapy restores fragile X protein production in human cells: Aberrant alternative splicing of messenger RNA plays fundamental role in fragile X syndrome

Antisense therapy restores fragile X protein production in human cells: Aberrant alternative splicing of messenger RNA plays fundamental role in fragile X syndrome
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Michael tranfagliaUmass chanHuseyin mehmetArthurf koskinasSimons foundation for autism researchNational institutes of healthResearch foundationBusiness developmentNational institutesSimons foundationAutism research

Antisense Therapy Restores Fragile X Protein Production in Human Cells

Antisense Therapy Restores Fragile X Protein Production in Human Cells
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Jonathank wattsUmass chanJoeld richterHuseyin mehmetSneha shahMichael tranfagliaElizabeth berry kravisArthurf koskinasUmass chan medical schoolUniversity medical centerProceedings of the national academy sciencesNational institutes of healthResearch foundationSimons foundation for autism researchBusiness developmentChan medical school

Community News – Rotary Club elects next president - Portland Press Herald

South Portland-Cape Elizabeth Rotary Club elected Jim Britt as its president for 2022-23. Britt will preside over a Rotary Club that in the previous year raised and donated about $86,000 to a variety of charitable organizations and activities. Club officers are vice president Nancy Irving (Cape Elizabeth), secretary Kathy Cotter (Cape Elizabeth) and treasurer Tom […]

United statesSouth portlandCape elizabethMaxine beecherLarry cliffordGloria twomeyTodd anguillyD cape elizabethJim brittRachel goguenRebecca millettPhillip smithPortland housing authorityCultural affairs committeeMaine council onSenior home modification program

Study shows fragile X treatment can incur resistance, suggests ways around it

Mark Bear, Picower Professor of Neuroscience at MIT, recalls the “eureka moment” 20 years ago when he realized that a severe developmental brain disorder

United statesAndy tranfagliaMichael tranfagliaRebecca senterPatrick mccamphillArnold heynenBroad instituteDepartment of brainNational institutes of healthCognitive sciencesPicower institute forColumbia universityUniversity of edinboroughResearch foundationMark bearPicower professor