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New details about how bacterial toxins cause life-threatening colitis January 8, 2021ScienceBlog.com Research led by scientists from UCLA and Harvard University has uncovered details about how the bacterium Clostridioides difficile causes excessive inflammation in the gut that can lead to potentially deadly colitis. Studying C. difficile toxin A, one of two toxins released by the bacterium, the researchers produced two key findings. They pinpointed which part of the toxic protein can permeate cell membranes to gain entry to cellular structures called endosomes, demonstrating that even fragments of the protein that contain that key segment are capable of accessing endosomes. In addition, they revealed how the toxin molecule causes inflammation, which has been a long-standing mystery because such molecules are generally quickly digested in the gut. The scientists found that toxin A and surprisingly even fragments of the toxin can organize DNA into ordered crystalline particles

New yorkUnited statesKishan patelCharlottef rabbXinhua chenJoshua hansenGerard wongWuhua xuEric yeeJun huangXiaotong yangDouglas golenbockCenters for diseaseNational institutes of healthHarvard medical schoolLawrence berkeley national laboratory